Association of a D2S2944 allele with depression specifically among those with substance abuse or antisocial personality

Douglas R Langbehn; Robert Philibert; Kristin M Caspers; Rebecca Yucuis; Remi J Cadoret

doi:10.1016/j.drugalcdep.2005.10.006

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Association of a D2S2944 allele with depression specifically among those with substance abuse or antisocial personality

Journal article

Peer reviewed

Association of a D2S2944 allele with depression specifically among those with substance abuse or antisocial personality

Douglas R Langbehn, Robert Philibert, Kristin M Caspers, Rebecca Yucuis and Remi J Cadoret

Drug and alcohol dependence, Vol.83(1), pp.33-41

2006

DOI: 10.1016/j.drugalcdep.2005.10.006

PMID: 16289859

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Abstract

Associations have previously been reported between a 124-bp allele at D2S2944 and recurrent, early-onset depression in women. These earlier reports also noted but did not emphasize a possible association between this allele and alcohol-specific depression. We have analyzed the Iowa Adoption Study data to test this association. D2S2944 allele typing was available for 247 subjects from the Iowa Adoption Studies. Information on lifetime affective, alcohol, drug, and antisocial personality (ASPD) disorders was available from a structured interview. We used logistic regression to analyze adjusted and interactive D2S2944 associations with depression. Controlling other risk factors, the 124-bp allele had a strong association with DSM-IV major depression specific to those with histories of alcohol abuse/dependence and/or ASPD. (Overlap between the two prevented further specification of the interaction.) The association was not gender-specific and was not limited to alcohol-related depressive episodes. This relationship appears stronger than the D2S2944 association previously reported for early-onset depression in women. We note that, in combination with additional liabilities towards depression in women and alcoholism/sociopathy in men, the 124-bp allele may provide a basis for the phenomenon of depressive spectrum illness proposed by Winokur.

Depression spectrum

Drug abuse

Genetic marker

Alcoholism

Antisocial personality

Linkage disequilibrium

Substance abuse

D2S2944

Logistic regression

Major depression

Genetic linkage

Risk factor

Genetics

Details

Title: Subtitle: Association of a D2S2944 allele with depression specifically among those with substance abuse or antisocial personality
Creators: Douglas R Langbehn - Department of Psychiatry, Psychiatry Research, Room 1-326, Medical Education Building, University of Iowa, Iowa City, IA 52242, USA
Robert Philibert - Department of Psychiatry, Psychiatry Research, Room 1-326, Medical Education Building, University of Iowa, Iowa City, IA 52242, USA
Kristin M Caspers - Department of Psychiatry, Psychiatry Research, Room 1-326, Medical Education Building, University of Iowa, Iowa City, IA 52242, USA
Rebecca Yucuis - Department of Psychiatry, Psychiatry Research, Room 1-326, Medical Education Building, University of Iowa, Iowa City, IA 52242, USA
Remi J Cadoret - Department of Psychiatry, Psychiatry Research, Room 1-326, Medical Education Building, University of Iowa, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: Drug and alcohol dependence, Vol.83(1), pp.33-41
DOI: 10.1016/j.drugalcdep.2005.10.006
PMID: 16289859
NLM abbreviation: Drug Alcohol Depend
ISSN: 0376-8716
eISSN: 1879-0046
Publisher: Elsevier Ireland Ltd
Language: English
Date published: 2006
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Psychiatry; Epidemiology; Iowa Neuroscience Institute
Record Identifier: 9984003414402771

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