Association of a Pathway-Specific Genetic Risk Score With Risk of Radiation-Associated Contralateral Breast Cancer

Gordon P Watt; Anne S Reiner; Susan A Smith; Daniel O Stram; Marinela Capanu; Kathleen E Malone; Charles F Lynch; Esther M John; Julia A Knight; Lene Mellemkjær; Leslie Bernstein; Jennifer D Brooks; Meghan Woods; Xiaolin Liang; Robert W Haile; Nadeem Riaz; David V Conti; Mark Robson; David Duggan; John D Boice; Roy E Shore; Marc Tischkowitz; Irene Orlow; Duncan C Thomas; Patrick Concannon; Jonine L Bernstein

doi:10.1001/jamanetworkopen.2019.12259

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Association of a Pathway-Specific Genetic Risk Score With Risk of Radiation-Associated Contralateral Breast Cancer

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Association of a Pathway-Specific Genetic Risk Score With Risk of Radiation-Associated Contralateral Breast Cancer

Gordon P Watt, Anne S Reiner, Susan A Smith, Daniel O Stram, Marinela Capanu, Kathleen E Malone, Charles F Lynch, Esther M John, Julia A Knight, Lene Mellemkjær, …

JAMA network open, Vol.2(9), pp.e1912259-e1912259

09/04/2019

DOI: 10.1001/jamanetworkopen.2019.12259

PMCID: PMC6777239

PMID: 31560388

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Abstract

This case-control study assesses the association of a genetic risk score based on variants in a DNA repair pathway with risk of a second primary contralateral breast cancer after radiation therapy for a first breast cancer.

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Title: Subtitle: Association of a Pathway-Specific Genetic Risk Score With Risk of Radiation-Associated Contralateral Breast Cancer
Creators: Gordon P Watt - Memorial Sloan Kettering Cancer Center
Anne S Reiner - Memorial Sloan Kettering Cancer Center
Susan A Smith - The University of Texas MD Anderson Cancer Center
Daniel O Stram - University of Southern California
Marinela Capanu - Memorial Sloan Kettering Cancer Center
Kathleen E Malone - Fred Hutch Cancer Center
Charles F Lynch - University of Iowa
Esther M John - Stanford Cancer Institute
Julia A Knight - Lunenfeld-Tanenbaum Research Institute
Lene Mellemkjær - University of Toronto
Leslie Bernstein - City Of Hope National Medical Center
Jennifer D Brooks - University of Toronto
Meghan Woods - Memorial Sloan Kettering Cancer Center
Xiaolin Liang - Memorial Sloan Kettering Cancer Center
Robert W Haile - Cedars-Sinai Medical Center
Nadeem Riaz - Memorial Sloan Kettering Cancer Center
David V Conti
Mark Robson - Memorial Sloan Kettering Cancer Center
David Duggan - Translational Genomics Research Institute
John D Boice - National Council on Radiation Protection and Measurements
Roy E Shore - New York University School of Medicine
Marc Tischkowitz - University of Cambridge
Irene Orlow - Memorial Sloan Kettering Cancer Center
Duncan C Thomas - University of Southern California
Patrick Concannon - University of Florida
Jonine L Bernstein - Memorial Sloan Kettering Cancer Center
Resource Type: Journal article
Publication Details: JAMA network open, Vol.2(9), pp.e1912259-e1912259
DOI: 10.1001/jamanetworkopen.2019.12259
PMID: 31560388
PMCID: PMC6777239
NLM abbreviation: JAMA Netw Open
ISSN: 2574-3805
eISSN: 2574-3805
Publisher: American Medical Association
Alternative title: Association of a Genetic Risk Score With Radiation-Associated Contralateral Breast Cancer
Language: English
Date published: 09/04/2019
Academic Unit: Epidemiology
Record Identifier: 9984214823602771

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