Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis

Howard J Edenberg; Xiaoling Xuei; Hui-Ju Chen; Huijun Tian; Leah Flury Wetherill; Danielle M Dick; Laura Almasy; Laura Bierut; Kathleen K Bucholz; Alison Goate; Victor Hesselbrock; Samuel Kuperman; John Nurnberger; Bernice Porjesz; John Rice; Marc Schuckit; Jay Tischfield; Henri Begleiter; Tatiana Foroud

doi:10.1093/hmg/ddl073

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Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis

Journal article

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Peer reviewed

Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis

Howard J Edenberg, Xiaoling Xuei, Hui-Ju Chen, Huijun Tian, Leah Flury Wetherill, Danielle M Dick, Laura Almasy, Laura Bierut, Kathleen K Bucholz, Alison Goate, …

Human molecular genetics, Vol.15(9), pp.1539-1549

05/01/2006

DOI: 10.1093/hmg/ddl073

PMID: 16571603

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Abstract

Linkage evidence indicated that gene(s) located on chromosome 4q, in the region of the alcohol dehydrogenase (ADH) genes, affected risk for alcoholism. We genotyped 110 single nucleotide polymorphisms (SNPs) across the seven ADH genes and analyzed their association with alcoholism in a set of families with multiple alcoholic members, using the pedigree disequilibrium test. There was strong evidence that variations in ADH4 are associated with alcoholism: 12 SNPs were significantly associated. The region of strongest association ran from intron 1 to 19.5 kb beyond the 3' end of the gene. Haplotype tag SNPs were selected for the block in the ADH4 gene that provided evidence of association and subsequently used in association analysis; the haplotype was significantly associated with alcoholism (P=0.01) There was weaker evidence that variations in ADH1A and ADH1B might also play a role in modifying risk. Among African-Americans, there was evidence that the ADH1B*3 allele was protective.

Haplotypes

Multigene Family

Alcoholism - enzymology

Humans

Alcohol Dehydrogenase - genetics

Alcoholism - genetics

Genotype

Polymorphism, Single Nucleotide

Details

Title: Subtitle: Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis
Creators: Howard J Edenberg - Indiana University School of Medicine, Indianapolis, USA. edenberg@iupui.edu
Xiaoling Xuei
Hui-Ju Chen
Huijun Tian
Leah Flury Wetherill
Danielle M Dick
Laura Almasy
Laura Bierut
Kathleen K Bucholz
Alison Goate
Victor Hesselbrock
Samuel Kuperman
John Nurnberger
Bernice Porjesz
John Rice
Marc Schuckit
Jay Tischfield
Henri Begleiter
Tatiana Foroud
Resource Type: Journal article
Publication Details: Human molecular genetics, Vol.15(9), pp.1539-1549
Publisher: England
DOI: 10.1093/hmg/ddl073
PMID: 16571603
ISSN: 0964-6906
eISSN: 1460-2083
Grant note: U10AA008401 / NIAAA NIH HHS
Language: English
Date published: 05/01/2006
Academic Unit: Psychiatry; Stead Family Department of Pediatrics
Record Identifier: 9984004191302771

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