Journal article
Association of amino acids with common complications of prematurity
Pediatric research, Vol.73(6), pp.700-705
06/2013
DOI: 10.1038/pr.2013.43
PMCID: PMC3660469
PMID: 23481552
Abstract
Tandem mass spectrometry has been proposed as a method of diagnosing or predicting the development of common complex neonatal diseases. Our objective was to identify metabolites associated with common complications of prematurity.
We performed a retrospective analysis of medical data and metabolite measurements from routine neonatal screening on 689 preterm (<37 wk of gestational age) neonates.
We observed higher levels of phenylalanine (PHE) in infants with respiratory distress syndrome (RDS; P = 1.7 × 10(-5)), the only association that was significant after correction for multiple testing. We found suggestive significance (P < 0.001) of higher essential amino acids in infants with patent ductus arteriosus (PDA). Functionality of these findings was explored in the ductus arteriosus (DA) isolated from term and preterm mouse pups. None of the amino acids had a direct vasodilatory effect on the isolated DA.
We found that newborns with RDS had higher levels of PHE that may be a result of impaired PHE hydroxylase activity. We also detected marginally higher levels of all measured essential amino acids in infants with PDA. We did not find dilation of the mouse ductus for these metabolites, indicating that instead of potentially causing PDA, they are probably serving as markers of catabolism.
Details
- Title: Subtitle
- Association of amino acids with common complications of prematurity
- Creators
- Kelli K Ryckman - Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA. kelli-ryckman@uiowa.eduJohn M DagleOleg A ShchelochkovNoah EhingerStanley D PooleStanton L BerberichJeff ReeseJeffrey C Murray
- Resource Type
- Journal article
- Publication Details
- Pediatric research, Vol.73(6), pp.700-705
- DOI
- 10.1038/pr.2013.43
- PMID
- 23481552
- PMCID
- PMC3660469
- NLM abbreviation
- Pediatr Res
- ISSN
- 1530-0447
- eISSN
- 1530-0447
- Publisher
- United States
- Grant note
- R01 HL-109199 / NHLBI NIH HHS K99 HD-065786 / NICHD NIH HHS P30 ES005605 / NIEHS NIH HHS R01 HD052953 / NICHD NIH HHS R01 HD-52953 / NICHD NIH HHS R00 HD065786 / NICHD NIH HHS K99 HD065786 / NICHD NIH HHS R01 HD057192 / NICHD NIH HHS R01 HD-57192 / NICHD NIH HHS R01 HL109199 / NHLBI NIH HHS
- Language
- English
- Date published
- 06/2013
- Academic Unit
- Anatomy and Cell Biology; International Programs; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Nursing; Public Policy Center (Archive); Biochemistry and Molecular Biology; Dental Research; Neonatology
- Record Identifier
- 9983996197602771
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