Association of amoxicillin use during early childhood with developmental tooth enamel defects

Liang Hong; Steven M Levy; John J Warren; Deborah V Dawson; George R Bergus; James S Wefel

doi:10.1001/archpedi.159.10.943

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Association of amoxicillin use during early childhood with developmental tooth enamel defects

Journal article

Open access

Peer reviewed

Association of amoxicillin use during early childhood with developmental tooth enamel defects

Liang Hong, Steven M Levy, John J Warren, Deborah V Dawson, George R Bergus and James S Wefel

Archives of pediatrics & adolescent medicine, Vol.159(10), pp.943-948

10/2005

DOI: 10.1001/archpedi.159.10.943

PMID: 16203939

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Abstract

It has been speculated that amoxicillin use could be associated with dental enamel defects. To assess the association between dental fluorosis, one of the most common developmental tooth enamel defects, and amoxicillin use during early childhood. As participants in the Iowa Fluoride Study, subjects were followed up from birth to 32 months using questionnaires every 3 to 4 months to gather information on fluoride intake and amoxicillin use. Early-erupting permanent teeth of 579 subjects were assessed for fluorosis using the Fluorosis Risk Index at approximately the age of 9 years. Relationships between fluorosis and amoxicillin use were assessed using relative risk (RR), Mantel-Haenszel stratified analyses, and multivariable logistic regression. Amoxicillin use was reported by 75% of subjects by 12 months and 91% by 32 months. Overall, 24% had fluorosis on both maxillary central incisors. Amoxicillin use from 3 to 6 months significantly increased the risk of fluorosis on the maxillary central incisors (RR = 2.04; 95% confidence interval [CI], 1.49-2.78). After adjusting for fluoride intake and otitis media, the risk of fluorosis on the maxillary central incisors from amoxicillin use during 3 to 6 months (Mantel-Haenszel RR = 1.85; 95% CI, 1.20-2.78) was still statistically significant. Multivariable logistic regression analyses confirmed the increased risk of fluorosis from amoxicillin use during 3 to 6 months (odds ratio = 2.50; 95% CI, 1.21-5.15); fluoride intake was also statistically significant. The findings from this study suggest a link between amoxicillin use during infancy and developmental enamel defects of permanent teeth; however, further research is needed.

Fluorosis, Dental - etiology

Humans

Breast Feeding

Logistic Models

Male

Otitis Media - drug therapy

Confounding Factors (Epidemiology)

Amoxicillin - adverse effects

Female

Anti-Bacterial Agents - adverse effects

Odds Ratio

Otitis Media - epidemiology

Child

Dental Enamel - drug effects

Details

Title: Subtitle: Association of amoxicillin use during early childhood with developmental tooth enamel defects
Creators: Liang Hong - Department of Preventive and Community Dentistry, Dows Institute for Dental Research, University of Iowa, Iowa City, IA 52242, USA
Steven M Levy
John J Warren
Deborah V Dawson
George R Bergus
James S Wefel
Resource Type: Journal article
Publication Details: Archives of pediatrics & adolescent medicine, Vol.159(10), pp.943-948
DOI: 10.1001/archpedi.159.10.943
PMID: 16203939
NLM abbreviation: Arch Pediatr Adolesc Med
ISSN: 1072-4710
eISSN: 1538-3628
Publisher: American Medical Association; United States
Grant note: R01 DE 09551 / NIDCR NIH HHS M01 RR 00059 / NCRR NIH HHS P30 DE 10126 / NIDCR NIH HHS R01 DE 12101 / NIDCR NIH HHS
Language: English
Date published: 10/2005
Academic Unit: Preventive and Community Dentistry; Physician Assistant Studies; Psychiatry; Epidemiology; Biostatistics; Pediatric Dentistry; Family and Community Medicine; Dental Research
Record Identifier: 9983917682902771

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