Journal article
Association of body mass index with serum anti-Mullerian hormone and inhibin B levels among 8323 women attending a reproductive medical center: a cross-sectional study
Endocrine, Vol.75(1), pp.284-292
01/01/2022
DOI: 10.1007/s12020-021-02839-2
PMID: 34363585
Abstract
Purpose To assess the association of body mass index (BMI) with serum anti-Mullerian hormone (AMH) and inhibin B (InB) levels among women attending a reproductive medical center. Methods We conducted a cross-sectional study of 8323 women (96.4% were Han race) without polycystic ovary syndrome (PCOS) from the reproductive medical center of Tongji Hospital in Wuhan, China for assisted reproductive technology treatment between January 2016 and May 2018. For each participant, BMI and levels of serum AMH and InB were measured at entry by trained clinical technicians. Multivariate linear regression models were used to quantitatively estimate the associations of continuous and categorical BMI with serum AMH and InB levels. Results Each 1 kg/m(2) increase in BMI was significantly associated with a 1.02% (95% CI: 0.40, 1.65%) and 3.59% (3.11, 4.06%) reduction in AMH and InB levels, respectively. No departure from linearity was observed for either AMH or InB (both P for nonlinear trend >0.05). Overweight and obesity were significantly associated with a 6.01% (0.70, 11.04%) and 18.64% (2.29, 32.26%) reduction in AMH level, and were significantly associated with a 18.80% (15.23, 22.23%) and a 35.44% (25.47, 44.08%) reduction in InB level, respectively. In addition, the association between BMI and AMH level was significantly stronger among women >= 32 years. Conclusions BMI was linearly and inversely associated with AMH and InB levels among women without PCOS. Both overweight and obesity were significantly associated with lower AMH and InB levels.
Details
- Title: Subtitle
- Association of body mass index with serum anti-Mullerian hormone and inhibin B levels among 8323 women attending a reproductive medical center: a cross-sectional study
- Creators
- Yaqi Wang - Sun Yat-sen UniversityLi Wu - Huazhong University of Science and Technology HospitalZhengyu Yang - University of MelbourneRuijun Xu - Sun Yat-sen UniversityYonggang Duan - University of Hong KongJiajia Lin - Sun Yat-sen UniversityXiuqing Cui - Hubei Provincial Center for Disease Control and PreventionChuangang Fan - Hubei Provincial Center for Disease Control and PreventionYun Zhou - First Affiliated Hospital of Guangzhou Medical UniversityWei Bao - University of IowaLei Jin - Huazhong University of Science and TechnologyYuewei Liu - Sun Yat-sen University
- Resource Type
- Journal article
- Publication Details
- Endocrine, Vol.75(1), pp.284-292
- Publisher
- Springer Nature
- DOI
- 10.1007/s12020-021-02839-2
- PMID
- 34363585
- ISSN
- 1355-008X
- eISSN
- 1559-0100
- Number of pages
- 9
- Grant note
- Center for Global and Regional Environmental Research at the University of Iowa 2018YFC1002103 / National Key Research and Development Program from Ministry of Science and Technology of China
- Language
- English
- Date published
- 01/01/2022
- Academic Unit
- Epidemiology
- Record Identifier
- 9984364385302771
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