Journal article
Association of calcium and vitamin D supplementation with cancer incidence and cause‐specific mortality in Black women: extended follow‐up of the Women's Health Initiative calcium‐vitamin D trial
International journal of cancer, Vol.153(5), pp.1035-1042
09/01/2023
DOI: 10.1002/ijc.34436
PMID: 36650676
Abstract
Low circulating vitamin D levels are more prevalent in Black than White individuals. We analyzed the Women's Health Initiative (WHI) calcium plus vitamin D (CaD) randomized clinical trial extended follow-up data to evaluate associations between calcium plus vitamin D supplementation and incident cancer, cardiovascular disease (CVD), and cause-specific mortality endpoints among Black women. Intent-to-treat analysis was performed. Among 3325 Black women in the CaD trial who were randomized into either daily calcium (1000 mg of calcium carbonate) plus vitamin D (400 IU D3) or placebos for an average of 7 years, there were 813 deaths, 588 incident cancers, and 837 CVD events during an average of 15.7 years of follow up (52 230 total person-years). Using Cox's proportional hazards models, we calculated hazard ratios and their confidence intervals for outcomes ascertained during the trial period, posttrial follow-up period and overall periods combined. We found that total mortality, cause-specific mortality, and total cancer incidence were almost identical between CaD and placebo groups. These results suggest that calcium plus vitamin D supplementation does not reduce risks of cancer, CVD, or other major causes of death in Black women overall and, thus, other medical, behavioral or social interventions should be considered to narrow health disparities related to these outcomes. However, other finer endpoints, such as colorectal cancer, warrants further investigation.
Details
- Title: Subtitle
- Association of calcium and vitamin D supplementation with cancer incidence and cause‐specific mortality in Black women: extended follow‐up of the Women's Health Initiative calcium‐vitamin D trial
- Creators
- Ikuko Kato - Wayne State UniversityJun Sun - University of Illinois at ChicagoTheresa A. Hastert - Wayne State UniversityJudy Abrams - Wayne State UniversityJoseph C. Larson - Fred Hutch Cancer CenterWei Bao - University of Science and Technology of ChinaAladdin H. Shadyab - Human LongevityCharles Mouton - The University of Texas Medical Branch at GalvestonLihong Qi - University of California, DavisLisa Warsinger Martin - George Washington UniversityJoAnn E. Manson - Brigham and Women's Hospital
- Resource Type
- Journal article
- Publication Details
- International journal of cancer, Vol.153(5), pp.1035-1042
- DOI
- 10.1002/ijc.34436
- PMID
- 36650676
- ISSN
- 0020-7136
- eISSN
- 1097-0215
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: HHSN 268201600004C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, HHSN268201600018C, P30 CA023074
- Language
- English
- Electronic publication date
- 01/17/2023
- Date published
- 09/01/2023
- Academic Unit
- Epidemiology
- Record Identifier
- 9984364363102771
Metrics
19 Record Views