Journal article
Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American population
Pediatric research, Vol.82(3), pp.554-559
09/2017
DOI: 10.1038/pr.2017.109
PMCID: PMC5570637
PMID: 28426651
Abstract
BackgroundPreterm birth (PTB) is the leading cause of neonatal mortality and morbidity. PTB is often classified according to clinical presentation as follows: idiopathic (PTB-I), preterm premature rupture of membranes (PTB-PPROM), and medically induced (PTB-M). The aim of this study was to evaluate the associations between specific candidate genes and clinical subtypes of PTB.MethodsTwenty-four single-nucleotide polymorphisms (SNPs) were genotyped in 18 candidate genes in 709 infant triads. Of them, 243 were PTB-I, 256 were PTB-PPROM, and 210 were PTB-M. These data were analyzed with a Family-Based Association.ResultsPTB was nominally associated with rs2272365 in PON1, rs883319 in KCNN3, rs4458044 in CRHR1, and rs610277 in F3. Regarding clinical subtypes analysis, three SNPs were associated with PTB-I (rs2272365 in PON1, rs10178458 in COL4A3, and rs4458044 in CRHR1), rs610277 in F3 was associated with PTB-PPROM, and rs883319 in KCNN3 and rs610277 in F3 were associated with PTB-M.ConclusionOur study identified polymorphisms potentially associated with specific clinical subtypes of PTB in this Latin American population. These results could suggest a specific role of such genes in the mechanisms involved in each clinical subtype. Further studies are required to confirm our results and to determine the role of these genes in the pathophysiology of clinical subtypes.
Details
- Title: Subtitle
- Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American population
- Creators
- Lucas G Gimenez - Laboratory of Genetic Epidemiology at Research Unit, CEMIC-CONICET (Centro de Educación Médica e Investigaciones Clínicas-Consejo Nacional de Investigaciones Científicas y Técnicas), Buenos Aires, ArgentinaAllison M Momany - Department of Pediatrics, University of Iowa, Iowa City, IowaFernando A Poletta - Laboratory of Genetic Epidemiology at Research Unit, CEMIC-CONICET (Centro de Educación Médica e Investigaciones Clínicas-Consejo Nacional de Investigaciones Científicas y Técnicas), Buenos Aires, ArgentinaHugo B Krupitzki - Laboratory of Genetic Epidemiology at Research Unit, CEMIC-CONICET (Centro de Educación Médica e Investigaciones Clínicas-Consejo Nacional de Investigaciones Científicas y Técnicas), Buenos Aires, ArgentinaJuan A Gili - Laboratory of Genetic Epidemiology at Research Unit, CEMIC-CONICET (Centro de Educación Médica e Investigaciones Clínicas-Consejo Nacional de Investigaciones Científicas y Técnicas), Buenos Aires, ArgentinaTamara D Busch - Department of Pediatrics, University of Iowa, Iowa City, IowaCesar Saleme - Maternity Nuestra Señora de la Merced, Tucumán, ArgentinaViviana R Cosentino - ECLAMC (Estudio Colaborativo Latinoamericano de Malformaciones Congénitas) at INAGEMP (Instituto Nacional de Genética Médica Populacional), Buenos Aires, ArgentinaMariela S Pawluk - Laboratory of Genetic Epidemiology at Research Unit, CEMIC-CONICET (Centro de Educación Médica e Investigaciones Clínicas-Consejo Nacional de Investigaciones Científicas y Técnicas), Buenos Aires, ArgentinaHebe Campaña - CIC (Comisión de Investigaciones Científicas), La Plata, Buenos Aires, ArgentinaEnrique C Gadow - Laboratory of Genetic Epidemiology at Research Unit, CEMIC-CONICET (Centro de Educación Médica e Investigaciones Clínicas-Consejo Nacional de Investigaciones Científicas y Técnicas), Buenos Aires, ArgentinaJeffrey C Murray - Department of Pediatrics, University of Iowa, Iowa City, IowaJorge S Lopez-Camelo - Laboratory of Genetic Epidemiology at Research Unit, CEMIC-CONICET (Centro de Educación Médica e Investigaciones Clínicas-Consejo Nacional de Investigaciones Científicas y Técnicas), Buenos Aires, Argentina
- Resource Type
- Journal article
- Publication Details
- Pediatric research, Vol.82(3), pp.554-559
- DOI
- 10.1038/pr.2017.109
- PMID
- 28426651
- PMCID
- PMC5570637
- NLM abbreviation
- Pediatr Res
- ISSN
- 0031-3998
- eISSN
- 1530-0447
- Publisher
- United States
- Grant note
- T32 GM108540 / NIGMS NIH HHS R01 HD052953 / NICHD NIH HHS
- Language
- English
- Date published
- 09/2017
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Iowa Neuroscience Institute; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research; Neonatology
- Record Identifier
- 9984025372202771
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