Journal article
Association of contralateral breast cancer risk with mammographic density defined at higher-than-conventional intensity thresholds
International journal of cancer, Vol.151(8), pp.1304-1309
03/22/2022
DOI: 10.1002/ijc.34001
PMCID: PMC9420749
PMID: 35315524
Abstract
Mammographic dense area (MDA) is an established predictor of future breast cancer risk. Recent studies have found that risk prediction might be improved by redefining MDA in effect at higher-than-conventional intensity thresholds. We assessed whether such higher-intensity MDA measures gave stronger prediction of subsequent contralateral breast cancer (CBC) risk using the Women's Environment, Cancer, and Radiation Epidemiology (WECARE) Study, a population-based CBC case-control study of ≥1 year survivors of unilateral breast cancer diagnosed between 1990 and 2008. Three measures of MDA for the unaffected contralateral breast were made at the conventional intensity threshold ("Cumulus") and at two sequentially higher-intensity thresholds ("Altocumulus" and "Cirrocumulus") using the CUMULUS software and mammograms taken up to 3 years prior to the first breast cancer diagnosis. The measures were fitted separately and together in multivariable-adjusted logistic regression models of CBC (252 CBC cases and 271 unilateral breast cancer controls). The strongest association with CBC was MDA defined using the highest intensity threshold, Cirrocumulus (odds ratio per adjusted SD [OPERA] 1.40, 95% CI 1.13-1.73); and the weakest association was MDA defined at the conventional threshold, Cumulus (1.32, 95% CI 1.05-1.66). In a model fitting the three measures together, the association of CBC with Cirrocumulus was unchanged (1.40, 95% CI 0.97-2.05), and the lower brightness measures did not contribute to the CBC model fit. These results suggest that MDA defined at a high-intensity threshold is a better predictor of CBC risk and has the potential to improve CBC risk stratification beyond conventional MDA measures. This article is protected by copyright. All rights reserved.
Details
- Title: Subtitle
- Association of contralateral breast cancer risk with mammographic density defined at higher-than-conventional intensity thresholds
- Creators
- Gordon P Watt - Memorial Sloan Kettering Cancer CenterJulia A Knight - University of TorontoTuong L Nguyen - The University of MelbourneAnne S Reiner - Memorial Sloan Kettering Cancer CenterKathleen E Malone - Fred Hutchinson Cancer Research Center, Seattle, Washington, USEsther M John - Stanford University School of MedicineCharles F Lynch - University of IowaJennifer D Brooks - University of TorontoMeghan Woods - Memorial Sloan Kettering Cancer CenterXiaolin Liang - Memorial Sloan Kettering Cancer CenterLeslie Bernstein - City Of Hope National Medical CenterMalcolm C Pike - Memorial Sloan Kettering Cancer CenterJohn L Hopper - University of TorontoJonine L Bernstein - Memorial Sloan Kettering Cancer Center
- Resource Type
- Journal article
- Publication Details
- International journal of cancer, Vol.151(8), pp.1304-1309
- DOI
- 10.1002/ijc.34001
- PMID
- 35315524
- PMCID
- PMC9420749
- NLM abbreviation
- Int J Cancer
- eISSN
- 1097-0215
- Grant note
- DOI: 10.13039/501100001184, name: Cure Cancer Australia Foundation, award: 1159399; DOI: 10.13039/100000054, name: National Cancer Institute, award: P30 CA008748, P30 CA08682, R01 129639, R01 CA129649, R01 CA14236, R01 CA168339, R01 CA97397, U01 CA83178
- Language
- English
- Electronic publication date
- 03/22/2022
- Academic Unit
- Epidemiology
- Record Identifier
- 9984230139202771
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