Association of diabetes mellitus with dementia- and non-dementia-related mortality amongst women: a secondary competing risks analysis of the California Teachers Study

Cathleen Morgan; Bradon Annegers; Matthew K Taylor; Sara Shuger Fox; Tyler J Titcomb

doi:10.1111/ene.16294

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Association of diabetes mellitus with dementia- and non-dementia-related mortality amongst women: a secondary competing risks analysis of the California Teachers Study

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Association of diabetes mellitus with dementia- and non-dementia-related mortality amongst women: a secondary competing risks analysis of the California Teachers Study

Cathleen Morgan, Bradon Annegers, Matthew K Taylor, Sara Shuger Fox and Tyler J Titcomb

European journal of neurology, Vol.31(7), e16294

07/2024

DOI: 10.1111/ene.16294

PMCID: PMC11161306

PMID: 38563189

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Abstract

The prevalence of dementia is rapidly increasing. Attempts to further understand modifiable risk factors such as diabetes mellitus (DM) are urgently needed to inform public health policies for prevention. Thus, the objective of the current study was to assess the relationship between DM and risk of dementia and non-dementia mortality amongst women in the California Teachers Study prospective cohort. Women (n = 124,509) aged 22-104 years at baseline were included. DM was ascertained from self-reported questionnaires and hospital-linked records. Dementia-related deaths were ascertained from state and national records. Competing risk regression models were used to estimate cause-specific hazard ratios and 95% confidence intervals for the association of DM with dementia- and non-dementia-related mortality. There were 10,511 total DM cases and 3625 deaths due to dementia over a mean of 21.3 years of follow-up. Fully adjusted cause-specific hazard ratios of the association with DM were 2.26 (2.01, 2.55) for dementia-related and 1.97 (1.89, 2.05) for the competing risk of non-dementia-related mortality. This association was strongest amongst participants with incident DM, younger age at baseline and higher alcohol consumption or who were overweight. In the California Teachers Study, women with DM had increased risk of mortality due to both dementia and non-dementia causes; however, the risk of mortality due to dementia was elevated compared to non-dementia causes only amongst participants with incident DM.

Dementia

Diabetes

Epidemiology

mortality

women

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Details

Title: Subtitle: Association of diabetes mellitus with dementia- and non-dementia-related mortality amongst women: a secondary competing risks analysis of the California Teachers Study
Creators: Cathleen Morgan - Department of Kinesiology, Central College, Pella, Iowa, USA
Bradon Annegers - Department of Kinesiology, Central College, Pella, Iowa, USA
Matthew K Taylor - University of Kansas
Sara Shuger Fox - Department of Kinesiology, Central College, Pella, Iowa, USA
Tyler J Titcomb - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA
Resource Type: Journal article
Publication Details: European journal of neurology, Vol.31(7), e16294
DOI: 10.1111/ene.16294
PMID: 38563189
PMCID: PMC11161306
NLM abbreviation: Eur J Neurol
eISSN: 1468-1331
Publisher: Wiley
Grant note: T32DK112751-05 / NIDDK NIH HHS K01AG065487 / NIA NIH HHS
Language: English
Electronic publication date: 04/02/2024
Date published: 07/2024
Academic Unit: Internal Medicine
Record Identifier: 9984581221602771

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