Journal article
Association of elevated mutagenesis in the spleen with genetic susceptibility to induced plasmacytoma development in mice
Cancer research (Chicago, Ill.), Vol.58(8), pp.1616-1619
1998
PMID: 9563470
Abstract
Using the phage lambdaLIZ-based transgenic in vivo mutagenesis assay, mean mutant rates were determined in the spleen of mice exposed to sustained oxidative stress and were found to be increased approximately 3-fold in plasmacytoma-susceptible BALB/c and C.D2-Idh1-Pep3 mice, but not in plasmacytoma-resistant DBA/2N mice. This finding suggests a correlation between the genetic susceptibility to inflammation-induced peritoneal plasmacytomagenesis and the phenotype of increased mutagenesis in lymphoid tissues, raising the possibility that plasmacytoma resistance genes may inhibit tumor development by minimizing oxidative mutagenesis in B cells.
Details
- Title: Subtitle
- Association of elevated mutagenesis in the spleen with genetic susceptibility to induced plasmacytoma development in mice
- Creators
- K FELIX - Laboratory of Genetics, DBS, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, United StatesK KELLIHER - Laboratory of Genetics, DBS, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, United StatesG.-W BORNKAMM - Institut für Klinishe Molekularbiologie and Tumorgenetik, GSF, Munich, GermanyS JANZ - Laboratory of Genetics, DBS, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, United States
- Resource Type
- Journal article
- Publication Details
- Cancer research (Chicago, Ill.), Vol.58(8), pp.1616-1619
- PMID
- 9563470
- NLM abbreviation
- Cancer Res
- ISSN
- 0008-5472
- eISSN
- 1538-7445
- Publisher
- American Association for Cancer Research
- Language
- English
- Date published
- 1998
- Academic Unit
- Pathology
- Record Identifier
- 9984083820602771
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