Association of elevated serumfree light chains with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis

Alyssa I Clay-Gilmour; Abdul R Rishi; Lynn R Goldin; Alexandra J Greenberg-Worisek; Sara J Achenbach; Kari G Rabe; Matthew J Maurer; Neil E Kay; Tait D Shanafelt; Timothy G Call; J. Brice Weinberg; Nicola J Camp; James R Cerhan; Jose Leis; Aaron Norman; David L Murray; S. Vincent Rajkumar; Neil E Caporaso; Ola Landgren; Mary L McMaster; Susan L Slager; Celine M Vachon

doi:10.1038/s41408-019-0220-x

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Association of elevated serumfree light chains with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis

Journal article

Open access

Peer reviewed

Association of elevated serumfree light chains with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis

Alyssa I Clay-Gilmour, Abdul R Rishi, Lynn R Goldin, Alexandra J Greenberg-Worisek, Sara J Achenbach, Kari G Rabe, Matthew J Maurer, Neil E Kay, Tait D Shanafelt, Timothy G Call, …

Blood cancer journal (New York), Vol.9(8), 59

08/05/2019

DOI: 10.1038/s41408-019-0220-x

PMCID: PMC6683199

PMID: 31383849

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Abstract

Chronic lymphocytic leukemia (CLL) and its precursor, monoclonal B-cell lymphocytosis (MBL), are heritable. Serumfree light-chain (sFLC) measures are a prognostic factor for CLL, but their role in susceptibility to CLL is not clear. We investigated differences between sFLC measurements in pre-treatment serum from five groups to inform the association of sFLC with familial and sporadic CLL: (1) familial CLL (n = 154), (2) sporadic CLL (n = 302), (3) familial MBL (n = 87), (4) unaffected first-degree relatives from CLL/MBL families (n = 263), and (5) reference population (n = 15,396). The percent of individuals having elevated monoclonal and polyclonal sFLCs was compared using age-stratified and age- and sex-adjusted logistic regression models. In age groups >50 years, monoclonal sFLC elevations were increased in sporadic and familial CLL cases compared to the reference population (p's < 0.05). However, there were no statistically significant differences in sFLC monoclonal or polyclonal elevations between familial and sporadic CLL cases (p's > 0.05). Unaffected relatives and MBL cases from CLL/MBL families, ages >60 years, showed elevated monoclonal sFLC, compared to the reference population (p's < 0.05). This is the first study to demonstrate monoclonal sFLC elevations in CLL cases compared to controls. Monoclonal sFLC levels may provide additional risk information in relatives of CLL probands.

Adult

Aged

Aged, 80 and over

B-Lymphocytes - immunology

B-Lymphocytes - pathology

Biomarkers, Tumor - blood

Biomarkers, Tumor - immunology

Case-Control Studies

Cohort Studies

Female

Humans

Immunoglobulin Light Chains - blood

Leukemia, Lymphocytic, Chronic, B-Cell - blood

Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology

Leukemia, Lymphocytic, Chronic, B-Cell - genetics

Leukemia, Lymphocytic, Chronic, B-Cell - immunology

Lymphocytosis - blood

Lymphocytosis - epidemiology

Lymphocytosis - genetics

Lymphocytosis - immunology

Male

Middle Aged

Minnesota - epidemiology

Details

Title: Subtitle: Association of elevated serumfree light chains with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis
Creators: Alyssa I Clay-Gilmour - Mayo Clinic
Abdul R Rishi - Mercy Medical Center
Lynn R Goldin - National Institutes of Health
Alexandra J Greenberg-Worisek - Division of Epidemiology, Department of Health Sciences, Mayo Clinic, Rochester, MN, USA
Sara J Achenbach - Mayo Clinic
Kari G Rabe - Mayo Clinic in Florida
Matthew J Maurer - Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA
Neil E Kay - Mayo Clinic
Tait D Shanafelt - Stanford University
Timothy G Call - Mayo Clinic
J. Brice Weinberg - Duke University
Nicola J Camp - Huntsman Cancer Institute
James R Cerhan - Division of Epidemiology, Department of Health Sciences, Mayo Clinic, Rochester, MN, USA.
Jose Leis - Mayo Clinic
Aaron Norman - Mayo Clinic
David L Murray - Mayo Clinic
S. Vincent Rajkumar - Division of Hematology, Mayo Clinic, Rochester, MN, 55905, USA
Neil E Caporaso - National Institutes of Health
Ola Landgren - Memorial Sloan Kettering Cancer Center
Mary L McMaster - National Institutes of Health
Susan L Slager - Mayo Clinic
Celine M Vachon - Mayo Clinic
Resource Type: Journal article
Publication Details: Blood cancer journal (New York), Vol.9(8), 59
DOI: 10.1038/s41408-019-0220-x
PMID: 31383849
PMCID: PMC6683199
NLM abbreviation: Blood Cancer J
ISSN: 2044-5385
eISSN: 2044-5385
Grant note: R01 CA092153 / NCI NIH HHS U01 CA118444 / NCI NIH HHS R01 CA134674 / NCI NIH HHS R25 CA092049 / NCI NIH HHS P30 CA008748 / NCI NIH HHS P50 CA097274 / NCI NIH HHS
Language: English
Date published: 08/05/2019
Academic Unit: Epidemiology
Record Identifier: 9984368077802771

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