Association of entry into hospice or palliative care consultation during acute care hospitalization with subsequent antibiotic utilization

Alexandre R. Marra; Gosia S. Clore; Erin Balkenende; Cassie Cunningham Goedken; Daniel J. Livorsi; Michihiko Goto; Mary S. Vaughan-Sarrazin; Ann Broderick; Eli N. Perencevich

doi:10.1016/j.cmi.2022.07.018

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Association of entry into hospice or palliative care consultation during acute care hospitalization with subsequent antibiotic utilization

Journal article

Open access

Peer reviewed

Association of entry into hospice or palliative care consultation during acute care hospitalization with subsequent antibiotic utilization

Alexandre R. Marra, Gosia S. Clore, Erin Balkenende, Cassie Cunningham Goedken, Daniel J. Livorsi, Michihiko Goto, Mary S. Vaughan-Sarrazin, Ann Broderick and Eli N. Perencevich

Clinical microbiology and infection, Vol.29(1), pp.107.e1-107.e7

01/2023

DOI: 10.1016/j.cmi.2022.07.018

PMID: 35931374

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Abstract

We aimed to estimate antibiotic use during the last 6 months of life for hospitalized patients under hospice or palliative care and identify potential targets (i.e. time points) for antibiotic stewardship during the end-of-life period. We conducted a retrospective cohort study of nationwide Veterans Affairs (VA) patients who died between January 1, 2014 and December 31, 2019 and who had been hospitalized within 6 months prior to death. Data from the VA's integrated electronic medical record were collected, including demographics, comorbid conditions, and duration of inpatient antibiotics administered, along with outpatient antibiotics dispensed. A propensity score–matched cohort analysis was conducted to compare antibiotic use between hospitalized patients placed into palliative care or hospice matched to hospitalized patients not receiving palliative care or hospice. There were 9808 and 40 796 propensity score–matched patient pairs in the hospice and palliative care groups, respectively. Within 14 days of placement or consultation, 41% (4040/9808) of hospice patients and 48% (19 735/40 796) of palliative care patients received at least one antibiotic, while 25% (2420/9808) matched nonhospice and 27% (10 991/40 796) matched nonpalliative care patients received antibiotics. Entry into hospice was independently associated with a 12% absolute increase in antibiotic prescribing, and entry into palliative care was associated with a 17% absolute increase during the 14 days post-entry vs. pre-entry period. We observed that patients receiving end-of-life care had high levels of antibiotic exposure across this VA population, particularly during admissions when they received hospice or palliative care consultation.

Antibiotic

End-of-life

Palliative care

Terminal illness

Details

Title: Subtitle: Association of entry into hospice or palliative care consultation during acute care hospitalization with subsequent antibiotic utilization
Creators: Alexandre R. Marra - Iowa City VA Health Care System
Gosia S. Clore - Iowa City VA Health Care System
Erin Balkenende - Iowa City VA Health Care System
Cassie Cunningham Goedken - Iowa City VA Health Care System
Daniel J. Livorsi - Iowa City VA Health Care System
Michihiko Goto - Iowa City VA Health Care System
Mary S. Vaughan-Sarrazin - Iowa City VA Health Care System
Ann Broderick - Iowa City VA Health Care System
Eli N. Perencevich - Iowa City VA Health Care System
Resource Type: Journal article
Publication Details: Clinical microbiology and infection, Vol.29(1), pp.107.e1-107.e7
Publisher: Elsevier Ltd
DOI: 10.1016/j.cmi.2022.07.018
PMID: 35931374
ISSN: 1198-743X
eISSN: 1469-0691
Language: English
Date published: 01/2023
Academic Unit: Infectious Diseases; Health Management and Policy; Epidemiology; General Internal Medicine; Internal Medicine
Record Identifier: 9984359701802771

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