Journal article
Association of hemoglobin and spontaneous closure of the ductus arteriosus during the transitional period in very low birth weight infants
Journal of neonatal-perinatal medicine, Vol.14(4), pp.493-502
11/12/2021
DOI: 10.3233/NPM-200518
PMID: 33523022
Abstract
OBJECTIVES: To determine the association between plasma hemoglobin (HB) at three time-points (birth, postnatal days 0–3 and 0–10) and spontaneous closure of the ductus arteriosus (sDAC). STUDY DESIGN: A retrospective case-control study of preterm infants born (2013–2016) between 24 and 29 weeks of gestational age (GA) was conducted in a level three perinatal center in Switzerland. We collected hemoglobin at birth, between days 0–3 and 0–10 in two distinct groups: (i) patients treated for a PDA and (ii) patients with spontaneous closure of the ductus arteriosus (sDAC). Antenatal and postnatal demographic data and neonatal morbidity were collected. Bivariate analysis was performed and a stepwise logistic regression was done to investigate factors associated with sDAC. RESULTS: We reviewed the medical chart of 184 premature infants of whom 146 (79.3%) satisfied eligibility criteria. Of these, 74 (51%) were classified as sDAC. Patients with sDAC were older (GA: 28 vs 27, p < 0.001), more stable (clinical risk index for babies score (CRIB score): 2 vs 5, p < 0.001) and had better clinical outcomes than patients who received treatment for a PDA. Infants in the sDAC group had a higher level of hemoglobin during the first ten postnatal days. Multiple logistic regression analysis revealed that lower HB level (day 0–10) were associated with failure of sDAC (p < 0.05). CONCLUSIONS: This is one of the first studies to highlight a potential association between hemoglobin during the transitional period and sDAC. The biological nature of this observation requires prospective clarification.
Details
- Title: Subtitle
- Association of hemoglobin and spontaneous closure of the ductus arteriosus during the transitional period in very low birth weight infants
- Creators
- S. Joye - University of LausanneP.J. McNamara - University of IowaR.E. Giesinger - University of IowaJ-F. Tolsa - University of LausanneN. Sekarski - University Hospital of Lausanne
- Resource Type
- Journal article
- Publication Details
- Journal of neonatal-perinatal medicine, Vol.14(4), pp.493-502
- DOI
- 10.3233/NPM-200518
- PMID
- 33523022
- ISSN
- 1934-5798
- eISSN
- 1878-4429
- Language
- English
- Date published
- 11/12/2021
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology; Internal Medicine
- Record Identifier
- 9984353929702771
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