Journal article
Association of histologic chorioamnionitis, increased levels of cord blood cytokines, and intracerebral hemorrhage in preterm neonates
Biology of the neonate, Vol.83(3), pp.166-170
2003
DOI: 10.1159/000068924
PMID: 12660432
Abstract
The objective of this study was to investigate in a prospectie study whether histological chorioamnionitis (ChA) is a risk factor predisposing for intracerebral hemorrhage (ICH), and whether ICH is associated with a systemic fetal inflammation in preterm neonates with a gestational age <32 weeks. 106 neonates were studied; 20 (18.9%) suffered from ICH. ChA occurred significantly more often in neonates with ICH compared to neonates without ICH (70.0 vs. 36.0%, p = 0.006). Neonates with ICH had significantly higher median levels of proinflammatory cytokines (IL-1β, IL-6 and IL-8) compared to neonates without ICH (p < 0.001 for all comparisons). We conclude that the development of ICH in preterm infants is associated with both ChA and high levels of proinflammatory cytokines at birth. Copyright © 2003 S. Karger AG, Basel.
Details
- Title: Subtitle
- Association of histologic chorioamnionitis, increased levels of cord blood cytokines, and intracerebral hemorrhage in preterm neonates
- Creators
- M. K Tauscher - Department of Neonatology, Children's Hospital, Hospitals of the City of Cologne, Germany.D Berg - Department of Neonatology, Children's Hospital, Hospitals of the City of Cologne, GermanyM Brockmann - Department of Pathology, Hospitals of the City of Cologne, GermanyS Seidenspinner - University Children's Hospital, Würzburg, GermanyC. P Speer - University Children's Hospital, Würzburg, GermanyP Groneck - Department of Neonatology, Children's Hospital, Hospitals of the City of Cologne, Germany
- Resource Type
- Journal article
- Publication Details
- Biology of the neonate, Vol.83(3), pp.166-170
- Publisher
- Karger
- DOI
- 10.1159/000068924
- PMID
- 12660432
- ISSN
- 0006-3126
- eISSN
- 1421-9727
- Language
- English
- Date published
- 2003
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359690102771
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