Association of leptin receptor gene polymorphisms with growth and feed efficiency in meat-type chickens

El Mostafa El Moujahid; Sirui Chen; Sihua Jin; Yue Lu; Dexiang Zhang; Congliang Ji; Ning Yang

doi:10.3382/ps.2013-03674

Back

Association of leptin receptor gene polymorphisms with growth and feed efficiency in meat-type chickens

Journal article

Open access

Peer reviewed

Association of leptin receptor gene polymorphisms with growth and feed efficiency in meat-type chickens

El Mostafa El Moujahid, Sirui Chen, Sihua Jin, Yue Lu, Dexiang Zhang, Congliang Ji and Ning Yang

Poultry science, Vol.93(8), pp.1910-1915

08/01/2014

DOI: 10.3382/ps.2013-03674

PMID: 24931961

Files and links (1)

url

https://doi.org/10.3382/ps.2013-03674View

Published (Version of record) Open Access

Abstract

Many genetic factors influence the growth and feed intake of birds. In the current study, we evaluated the association of 8 previously reported SNP in the chicken leptin receptor (LEPR) gene with BW, BW gain (BWG), feed intake (FI), and feed conversion ratio (FCR). Four SNP with a very low minor allele frequency were removed by genotype quality control. The experimental population consisted of 796 pedigreed males from 2 genetically unrelated yellow meat-type chicken strains, 335 chickens from N202, and 461 chickens from N301. The BW at 49 (BW49) and 70 d of age (BW70) and FI (from 49 to 70 d of age) were measured individually. The BWG and FCR were calculated based on BW and FI in the interval between 49 to 70 d. The results indicated that rs14657336, rs13684613, rs13684615, and rs13684616 were found in strong linkage disequilibrium. This linkage disequilibrium block was significantly associated with BW49 (P < 0.05), BW70 (P < 0.05), and FI (P < 0.05) in the N202 strain, and FCR (P < 0.01) in the N301 strain, respectively. In addition, the GTACGTAC diplotype had the highest BWG and FI in both strains. The association revealed in this study suggests the need for further functional study on the role of LEPR gene in regulating feed intake and FCR of chickens.

Animal Nutritional Physiological Phenomena

Animals

Chickens - genetics

Chickens - growth & development

Chickens - physiology

Digestion

Eating

Male

Polymorphism, Genetic

Polymorphism, Single Nucleotide

Receptors, Leptin - genetics

Weight Gain

Details

Title: Subtitle: Association of leptin receptor gene polymorphisms with growth and feed efficiency in meat-type chickens
Creators: El Mostafa El Moujahid - China Agricultural University
Sirui Chen - China Agricultural University
Sihua Jin - China Agricultural University
Yue Lu - China Agricultural University
Dexiang Zhang - Wen's Food Group (China)
Congliang Ji - Wen's Food Group (China)
Ning Yang - National Engineering Laboratory for Animal Breeding and MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China nyang@cau.edu.cn
Resource Type: Journal article
Publication Details: Poultry science, Vol.93(8), pp.1910-1915
DOI: 10.3382/ps.2013-03674
PMID: 24931961
NLM abbreviation: Poult Sci
ISSN: 0032-5791
eISSN: 1525-3171
Language: English
Date published: 08/01/2014
Academic Unit: Biochemistry and Molecular Biology
Record Identifier: 9985150300702771

Metrics

1 Record Views

20 Times Cited - Web of Science