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Association of low shunt burden from PDA and adverse outcomes in premature infants
Journal article   Open access   Peer reviewed

Association of low shunt burden from PDA and adverse outcomes in premature infants

Chase Brandt, Hatice Dilara Mat, Adrianne R Bischoff, Patrick J McNamara and Danielle R Rios
Journal of perinatology, Vol.46(3), pp.364-369
03/2026
DOI: 10.1038/s41372-025-02437-4
PMCID: PMC12628839
PMID: 40975717
Appears in  UI Libraries Support Open Access
url
https://doi.org/10.1038/s41372-025-02437-4View
Published (Version of record) Open Access

Abstract

Objective Compare the incidence of death or adverse respiratory outcome in patients with low shunt burden from PDA to those with no PDA and evaluate secondary outcomes associated with PDA between groups. Study design Retrospective cohort study of all infants born <30 weeks gestation from 8/2018 to 5/2023 with TNE in the first postnatal week. Two groups: no PDA burden and low PDA burden. Primary outcome was composite of death or adverse respiratory outcome. Results 112 infants [no PDA (n = 69), low PDA burden (n = 43)] with mean gestational age and birth weight 27 ± 2 weeks and 1006 ± 310 g, respectively, were included. Baseline demographics were comparable with no difference in primary outcome (p = 0.2). Conclusion Prolonged exposure to low-volume PDA shunt was not associated with increased risk of death or abnormal respiratory outcome. Findings highlight the importance of redefining eligibility criteria for PDA trials, based on adjudication of shunt volume, to limit enrollment to patients with moderate- to high-volume shunts.
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