Journal article
Association of maternal pre-pregnancy or first trimester body mass index with neurodevelopmental impairment or death in extremely low gestational age neonates
Journal of perinatology, Vol.44(6), pp.802-810
02/23/2024
DOI: 10.1038/s41372-024-01905-7
PMCID: PMC11742262
PMID: 38396053
Abstract
Objective
To compare the rates of death or survival with severe neurodevelopmental impairment (sNDI) at 2 years among extremely preterm infants in relation to pre-pregnancy or first-trimester maternal body mass index (BMI).
Methods
This retrospective cohort study included extremely preterm infants (gestational age 220/7–266/7 weeks). The study was conducted at National Institute of Child Health and Human Development Neonatal Research Network sites. The primary outcome was death or sNDI at 2 years.
Results
Data on the primary outcome were available for 1208 children. Death or sNDI was not different among the three groups: 54.9% in normal, 56.1% in overweight, and 53.4% in obese group (p = 0.39). There was no significant difference in mortality, sNDI, moderate/severe cerebral palsy, Bayley Scales of Infant Development (BSID)-III cognitive composite score <70, BSID-III language composite score <70 in adjusted models.
Conclusion
Neurodevelopmental outcome was not significantly associated with maternal pre-pregnancy BMI among extreme preterm infants.
Details
- Title: Subtitle
- Association of maternal pre-pregnancy or first trimester body mass index with neurodevelopmental impairment or death in extremely low gestational age neonates
- Creators
- Sanjay Chawla - Wayne State UniversityAbbot R Laptook - Brown UniversityEmily A Smith - RTI InternationalSylvia Tan - RTI InternationalGirija Natarajan - Wayne State UniversityMyra H Wyckoff - The University of Texas Southwestern Medical CenterRachel G Greenberg - Duke UniversityNamasivayam Ambalavanan - University of Alabama at BirminghamEdward F Bell - Department of Pediatrics, University of Iowa, Iowa City, IA, USAKrisa P Van Meurs - Stanford University School of MedicineSusan R Hintz - Stanford University School of MedicineBetty R Vohr - Brown UniversityErika F Werner - Tufts Medical CenterAbhik Das - RTI InternationalSeetha Shankaran - The University of Texas at AustinNICHD Neonatal Research Network
- Resource Type
- Journal article
- Publication Details
- Journal of perinatology, Vol.44(6), pp.802-810
- DOI
- 10.1038/s41372-024-01905-7
- PMID
- 38396053
- PMCID
- PMC11742262
- NLM abbreviation
- J Perinatol
- eISSN
- 1476-5543
- Grant note
- UG1 HD27904 / U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) UG1 HD36790 / U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) UG1 HD53109 / U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) UG1 HD21385 / U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) UG1 HD34216 / U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) UG1 HD40492 / U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) UG1 HD27880 / U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) UL1 TR6, UL1 TR41, UL1 TR42, UL1 TR77, UL1 TR93, UL1 TR105, UL1 TR442, UL1 TR454, UL1 TR1117 / U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UG1 HD40689 / U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- Language
- English
- Electronic publication date
- 02/23/2024
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984561660002771
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