Journal article
Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis
The American journal of clinical nutrition, Vol.119(1), pp.221-231
01/01/2024
DOI: 10.1016/j.ajcnut.2023.10.011
PMCID: PMC10808817
PMID: 37890672
Abstract
Copper (Cu), an essential trace mineral regulating multiple actions of inflammation and oxidative stress, has been implicated in risk for preterm birth (PTB).
This study aimed to determine the association of maternal Cu concentration during pregnancy with PTB risk and gestational duration in a large multicohort study including diverse populations.
Maternal plasma or serum samples of 10,449 singleton live births were obtained from 18 geographically diverse study cohorts. Maternal Cu concentrations were determined using inductively coupled plasma mass spectrometry. The associations of maternal Cu with PTB and gestational duration were analyzed using logistic and linear regressions for each cohort. The estimates were then combined using meta-analysis. Associations between maternal Cu and acute-phase reactants (APRs) and infection status were analyzed in 1239 samples from the Malawi cohort.
The maternal prenatal Cu concentration in our study samples followed normal distribution with mean of 1.92 μg/mL and standard deviation of 0.43 μg/mL, and Cu concentrations increased with gestational age up to 20 wk. The random-effect meta-analysis across 18 cohorts revealed that 1 μg/mL increase in maternal Cu concentration was associated with higher risk of PTB with odds ratio of 1.30 (95% confidence interval [CI]: 1.08, 1.57) and shorter gestational duration of 1.64 d (95% CI: 0.56, 2.73). In the Malawi cohort, higher maternal Cu concentration, concentrations of multiple APRs, and infections (malaria and HIV) were correlated and associated with greater risk of PTB and shorter gestational duration.
Our study supports robust negative association between maternal Cu and gestational duration and positive association with risk for PTB. Cu concentration was strongly correlated with APRs and infection status suggesting its potential role in inflammation, a pathway implicated in the mechanisms of PTB. Therefore, maternal Cu could be used as potential marker of integrated inflammatory pathways during pregnancy and risk for PTB.
Details
- Title: Subtitle
- Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis
- Creators
- Nagendra K. Monangi - Cincinnati Children's Hospital Medical CenterHuan Xu - Cincinnati Children's Hospital Medical CenterYue-Mei Fan - Tampere UniversityRasheeda Khanam - Johns Hopkins UniversityWaqasuddin Khan - Aga Khan UniversitySaikat Deb - Public Health Laboratory Ivo de CarneriJesmin Pervin - International Centre for Diarrhoeal Disease ResearchJoan T. Price - University of North Carolina at Chapel HillLovejeet Kaur - Translational Health Science and Technology InstituteJose Villar - University of OxfordRose McGready - Mahidol Oxford Tropical Medicine Research UnitFernando C. Barros - Universidade Católica de PelotasCesar G. Victora - Universidade Federal de PelotasShama Munim - Aga Khan UniversityAris T. Papageorgh - University of OxfordRoseline Ochieng - Aga Khan University NairobiRachel Craik - University of OxfordHellen C. Barososio - Centre for Global Health ResearchJames A. Berkley - Kenya Medical Research InstituteMaria Carvalho - Aga Khan University NairobiLeila Cheikh Ismail - University of SharjahAnn Lambert - Aga Khan UniversityShane A. Norris - University of the WitwatersrandChrystelle OO Tshivuila-Matela - University of OxfordFrancois Nosten - Mahidol UniversityRicardo Uauy - London School of Hygiene & Tropical MedicineZulfiqar A. Bhutta - Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Headington, Oxford, United KingdomStephen Kennedy - University of OxfordAbdullah Al Mahmud - International Centre for Diarrhoeal Disease ResearchLe Quang Thanh - Tu Du Hospital, Ho Chi Ming City, VietnamAngharad Care - University of LiverpoolJulio A. Landero - University of CincinnatiGerald F. Combs - Jean Mayer Human Nutrition Research Center on AgingElizabeth Belling - Cincinnati Children's Hospital Medical CenterJoanne Chappell - Cincinnati Children's Hospital Medical CenterJing Chen - Cincinnati Children's Hospital Medical CenterFansheng Kong - Cincinnati Children's Hospital Medical CenterCraig Lacher - Grand Forks Human Nutrition Research CenterSalahuddin Ahmed - Biomedical Research FoundationNabidul Haque Chowdhury - Biomedical Research FoundationSayedur Rahman - Biomedical Research FoundationFurqan Kabir - Aga Khan UniversityImran Nisar - Aga Khan UniversityAneeta Hotwani - Aga Khan UniversityUsma Mehmood - Aga Khan UniversityAmbreen Nizar - Aga Khan UniversityJavairia Khalid - Aga Khan UniversityUsha Dhingra - Center for Public Health Kinetics, New Delhi, IndiaArup Dutta - Center for Public Health Kinetics, New Delhi, IndiaSaid Mohamed Ali - University of ZambiaFahad Aftab - Public Health Laboratory Ivo de CarneriMohammed Hamad Juma - Public Health Laboratory Ivo de CarneriMonjur Rahman - International Centre for Diarrhoeal Disease ResearchTahmeed Ahmed - International Centre for Diarrhoeal Disease ResearchM Munirul Islam - International Centre for Diarrhoeal Disease ResearchBellington Vwalika - University of ZambiaPatrick Musonda - University of ZambiaUlla Ashorn - Tampere UniversityKenneth Maleta - University of MalawiMikko Hallman - University of OuluLaura Goodfellow - University of LiverpoolJuhi K. Gupta - University of LiverpoolAna Alfirevic - Johns Hopkins UniversitySusan K. Murphy - Duke Medical CenterLarry Rand - University of California, San FranciscoKelli K. Ryckman - University of IowaJeffrey C. Murray - University of IowaRajiv Bahl - World Health OrganizationJames A. Litch - Kenya Medical Research InstituteCourtney Baruch-Gravett - Public Health Laboratory Ivo de CarneriShailaja Sopory - Translational Health Science and Technology InstituteUma Chandra Mouli Natchu - St. John's Research Institute (SJRI), Bangladore, IndiaPavitra V. Kumar - Public Health Laboratory Ivo de CarneriNeha Kumari - Public Health Laboratory Ivo de CarneriRamachandran Thiruvengadam - Public Health Laboratory Ivo de CarneriAtul Kumar Singh - Public Health Laboratory Ivo de CarneriPankaj Kumar - Public Health Laboratory Ivo de CarneriZarko Alfirevic - University of LiverpoolAbdullah H. Baqui - Johns Hopkins UniversityShinjini Bhatnagar - Public Health Laboratory Ivo de CarneriJane E. Hirst - University of OxfordCathrine Hoyo - North Carolina State UniversityFyezah Jehan - Aga Khan UniversityLaura Jelliffe-Pawlowski - University of California, San FranciscoAnisur Rahman - Public Health Laboratory Ivo de CarneriDaniel E. Roth - Centre for Global Health ResearchSunil Sazawal - Research Division, Public Health Laboratory, Center for Public Health Kinetics, Chake Chake, TanzaniaJeffrey S.A. Stringer - University of North Carolina at Chapel HillPer Ashorn - Tampere UniversityGe Zhang - University of OxfordLouis J. Muglia - Burroughs Wellcome FundINTERBIO-21st Study Consortium
- Resource Type
- Journal article
- Publication Details
- The American journal of clinical nutrition, Vol.119(1), pp.221-231
- DOI
- 10.1016/j.ajcnut.2023.10.011
- PMID
- 37890672
- PMCID
- PMC10808817
- NLM abbreviation
- Am J Clin Nutr
- ISSN
- 0002-9165
- eISSN
- 1938-3207
- Publisher
- Elsevier Inc
- Number of pages
- 11
- Language
- English
- Date published
- 01/01/2024
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9985034984302771
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