Journal article
Association of maternal prenatal selenium concentration and preterm birth: a multicountry meta-analysis
BMJ global health, Vol.6(9), p.e005856
09/2021
DOI: 10.1136/bmjgh-2021-005856
PMCID: PMC8438754
PMID: 34518202
Abstract
Selenium (Se), an essential trace mineral, has been implicated in preterm birth (PTB). We aimed to determine the association of maternal Se concentrations during pregnancy with PTB risk and gestational duration in a large number of samples collected from diverse populations.
Gestational duration data and maternal plasma or serum samples of 9946 singleton live births were obtained from 17 geographically diverse study cohorts. Maternal Se concentrations were determined by inductively coupled plasma mass spectrometry analysis. The associations between maternal Se with PTB and gestational duration were analysed using logistic and linear regressions. The results were then combined using fixed-effect and random-effect meta-analysis.
In all study samples, the Se concentrations followed a normal distribution with a mean of 93.8 ng/mL (SD: 28.5 ng/mL) but varied substantially across different sites. The fixed-effect meta-analysis across the 17 cohorts showed that Se was significantly associated with PTB and gestational duration with effect size estimates of an OR=0.95 (95% CI: 0.9 to 1.00) for PTB and 0.66 days (95% CI: 0.38 to 0.94) longer gestation per 15 ng/mL increase in Se concentration. However, there was a substantial heterogeneity among study cohorts and the random-effect meta-analysis did not achieve statistical significance. The largest effect sizes were observed in UK (Liverpool) cohort, and most significant associations were observed in samples from Malawi.
While our study observed statistically significant associations between maternal Se concentration and PTB at some sites, this did not generalise across the entire cohort. Whether population-specific factors explain the heterogeneity of our findings warrants further investigation. Further evidence is needed to understand the biologic pathways, clinical efficacy and safety, before changes to antenatal nutritional recommendations for Se supplementation are considered.
Details
- Title: Subtitle
- Association of maternal prenatal selenium concentration and preterm birth: a multicountry meta-analysis
- Creators
- Nagendra Monangi - Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USAHuan Xu - Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USARasheda Khanam - International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USAWaqasuddin Khan - Biorepository and Omics Research Group, Department of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, Sindh, PakistanSaikat Deb - Research Division, Public Health Laboratory, Center for Public Health Kinetics, Chake Chake, TanzaniaJesmin Pervin - Maternal and Child Health Division, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Dhaka District, BangladeshJoan T Price - Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USAStephen H Kennedy - INTERBIO-21st Study Consortium, Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UKAbdullah Al Mahmud - Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Dhaka District, BangladeshYuemei Fan - Center for Child Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Pirkanmaa, FinlandThanh Q Le - Benh Vien Tu Du, Ho Chi Minh City, Viet NamAngharad Care - Department of Women's and Children's Health, University of Liverpool, Liverpool, UKJulio A Landero - Department of Chemistry, University of Cincinnati, Cincinnati, Ohio, USAGerald F Combs - Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Medford, Massachusetts, USAElizabeth Belling - Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USAJoanne Chappell - Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USAFansheng Kong - Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USACriag Lacher - Grand Forks Human Nutrition Research Center, USDA ARS, Grand Forks, North Dakota, USASalahuddin Ahmed - Projahnmo Research Foundation, Dhaka, BangladeshNabidul Haque Chowdhury - Projahnmo Research Foundation, Dhaka, BangladeshSayedur Rahman - Projahnmo Research Foundation, Dhaka, BangladeshFurqan Kabir - Biorepository and Omics Research Group, Department of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, Sindh, PakistanImran Nisar - Biorepository and Omics Research Group, Department of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, Sindh, PakistanAneeta Hotwani - Biorepository and Omics Research Group, Department of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, Sindh, PakistanUsma Mehmood - Biorepository and Omics Research Group, Department of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, Sindh, PakistanAmbreen Nizar - Biorepository and Omics Research Group, Department of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, Sindh, PakistanJavairia Khalid - Biorepository and Omics Research Group, Department of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, Sindh, PakistanUsha Dhingra - Center for Public Health Kinetics, New Delhi, IndiaArup Dutta - Center for Public Health Kinetics, New Delhi, IndiaSaid Ali - Research Division, Public Health Laboratory, Center for Public Health Kinetics, Chake Chake, TanzaniaFahad Aftab - Research Division, Public Health Laboratory, Center for Public Health Kinetics, Chake Chake, TanzaniaMohammed Hamad Juma - Research Division, Public Health Laboratory, Center for Public Health Kinetics, Chake Chake, TanzaniaMonjur Rahman - Nutritional and Clinical Services Division, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Dhaka District, BangladeshBellington Vwalika - School of Medicine, University of Zambia, Lusaka, ZambiaPatrick Musonda - School of Public Health, University of Zambia, Lusaka, ZambiaTahmeed Ahmed - Cardiology, ICDDR,B, Dhaka, BangladeshMd Munirul Islam - Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, BangladeshUlla Ashorn - University of Tampere, Tampere, Pirkanmaa, FinlandKenneth Maleta - School of Public Health, University of Malawi College of Medicine, Blantyre, MalawiMikko Hallman - Medical Research Centre Oulu, PEDEGO Research Unit, University of Oulu, Oulu, Pohjois-Pohjanmaa, FinlandLaura Goodfellow - Department of Women's and Children's Health, University of Liverpool, Liverpool, Merseyside, UKJuhi K Gupta - Department of Women's and Children's Health, University of Liverpool, Liverpool, Merseyside, UKAna Alfirevic - Department of Women's and Children's Health, University of Liverpool, Liverpool, Merseyside, UKSusan Murphy - Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USALarry Rand - Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California, USAKelli K Ryckman - Department of Epidemiology, University of Iowa, Iowa City, Iowa, USAJeffrey C Murray - Department of Pediatrics, University of Iowa, Iowa City, Iowa, USARajiv Bahl - Department of Medicine, World Health Organization, Geneva, SwitzerlandJames A Litch - Global Alliance to Prevent Prematurity and Stillbirth, Lynnwood, Washington, USACourtney Baruch-Gravett - Global Alliance to Prevent Prematurity and Stillbirth, Lynnwood, Washington, USAZarko Alfirevic - Division of Perinatal Medicine, University of Liverpool, Liverpool, UKPer Ashorn - Department of Pediatrics, Tampere University Hospital, Tampere, FinlandAbdullah Baqui - International Center for Maternal and Newborn Health, Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USAJane Hirst - Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UKCathrine Hoyo - Department of Biological Sciences and Center for Human Health and the Enivironment, North Carolina State University, Raleigh, North Carolina, USAFyezah Jehan - Department of Pediatrics and Child Health, Aga Khan University, Karachi, PakistanLaura L Jelliffe-Pawlowski - Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USAAnisur Rahman - Maternal and Child Health Division, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Dhaka District, BangladeshDaniel E Roth - Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, CanadaSunil Sazawal - Research Division, Public Health Laboratory, Center for Public Health Kinetics, Chake Chake, TanzaniaJeffrey Stringer - Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USAGe Zhang - Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USALouis Muglia - Burroughs Wellcome Fund, Research Triangle Park, North Carolina, USAINTERBIO-21st Study Consortium
- Resource Type
- Journal article
- Publication Details
- BMJ global health, Vol.6(9), p.e005856
- DOI
- 10.1136/bmjgh-2021-005856
- PMID
- 34518202
- PMCID
- PMC8438754
- NLM abbreviation
- BMJ Glob Health
- ISSN
- 2059-7908
- eISSN
- 2059-7908
- Grant note
- P30 ES025128 / NIEHS NIH HHS P01 ES022831 / NIEHS NIH HHS R01 ES016772 / NIEHS NIH HHS R01 DK085173 / NIDDK NIH HHS R21 ES014947 / NIEHS NIH HHS 001 / World Health Organization
- Language
- English
- Date published
- 09/2021
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984213364402771
Metrics
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