Journal article
Association of mental health with clinical outcomes in hospitalized patients with moderate COVID-19
Journal of affective disorders, Vol.312, pp.331-336
09/01/2022
DOI: 10.1016/j.jad.2022.05.047
PMCID: PMC9098941
PMID: 35577158
Abstract
Objective: To assess the association of depression and anxiety with clinical outcomes and laboratory markers among hospitalized patients with coronavirus disease 2019 (COVID-19).Methods: A prospective cohort study in Wuhan, China was conducted in 205 adult hospitalized patients with a diagnosis of moderate coronavirus disease from admission through discharge or death. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS). The primary outcome was the incidence of severe or critical COVID-19, and the secondary outcomes were increased length of hospital stay and altered laboratory markers during follow up.Results: Among the 205 hospitalized patients (mean age 58 years; 51.7% male), 25 (12.2%) developed severe or critical COVID-19. According to the HADS scores, 51 (24.9%) and 92 (44.9%) of participants presented with clinically significant anxiety and depression, respectively. Using multi-variable adjusted Cox regression analysis, the adjusted hazard ratio of developing severe or critical COVID-19 associated with anxiety and depression was 1.55 (95% CI: 0.63, 3.80) and 4.28 (95% CI: 1.20, 15.30), respectively. The risk of developing severe or critical COVID-19 with both anxiety and depression was more than four times higher than in patients without anxiety or depression (HR, 4.05; 95% CI: 1.02, 16.00). In addition, both the trends of depression and anxiety were positively associated with a prolonged duration of hospitalization, and immune response was significantly decreased in patients with depression than those without.Conclusions: In patients having coronavirus disease, depression was associated with worse clinical outcomes. These findings highlight the importance of prevention and management of mental health problems in con-fronting the COVID-19 pandemic.
Details
- Title: Subtitle
- Association of mental health with clinical outcomes in hospitalized patients with moderate COVID-19
- Creators
- Tingting Li - Wuhan UniversityLi Zhang - Integrated Chinese Medicine (China)Sijie Cai - Wuhan University of Science and TechnologyZijian Lu - Wuhan UniversityWei Bao - University of IowaZhenli Guo - Hubei Provincial Hospital of Integrative MedicineShuang Rong - Wuhan University of Science and Technology
- Resource Type
- Journal article
- Publication Details
- Journal of affective disorders, Vol.312, pp.331-336
- DOI
- 10.1016/j.jad.2022.05.047
- PMID
- 35577158
- PMCID
- PMC9098941
- NLM abbreviation
- J Affect Disord
- ISSN
- 0165-0327
- eISSN
- 1573-2517
- Publisher
- Elsevier
- Number of pages
- 6
- Language
- English
- Date published
- 09/01/2022
- Academic Unit
- Epidemiology
- Record Identifier
- 9984363592502771
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