Journal article
Association of microtia with maternal nutrition
Birth defects research. A Clinical and molecular teratology, Vol.94(12), pp.1026-1032
12/2012
DOI: 10.1002/bdra.23053
PMID: 22821770
Abstract
BACKGROUND
Few studies have investigated the potential association of maternal dietary intake and risk of microtia among offspring.
METHODS
The study included deliveries from 1997 to 2005 from the National Birth Defects Prevention Study. Nonsyndromic cases of microtia were compared to nonmalformed, population-based, live-born control infants by estimating adjusted odds ratios (ORs) and 95% confidence intervals (CIs) from logistic regression models that included maternal race or ethnicity, education, folic acid–containing supplement intake, fertility treatment, study site, and total energy intake.
RESULTS
Comparing intake in the lowest 10th percentile versus the 10th to 90th percentiles, lower maternal intakes of carbohydrate (OR, 1.59; 95% CI, 1.07–2.38) and dietary folate (OR, 1.57; 95% CI, 1.09–2.25) were associated with elevated risk of microtia. In addition, results suggested that higher diet quality (as measured by the Diet Quality Index, and comparing the highest with the lowest quartile) was protective, but the CI did not exclude one (OR, 0.73; 95% CI, 0.50–1.07). Results were similar among obese and nonobese women.
CONCLUSIONS
These data contribute to the limited body of evidence regarding the potential contribution of maternal nutrition to the etiology of microtia.
Details
- Title: Subtitle
- Association of microtia with maternal nutrition
- Creators
- Chen Ma - Department of Pediatrics, Stanford University, Stanford, CaliforniaGary M Shaw - Department of Pediatrics, Stanford University, Stanford, CaliforniaAngela E Scheuerle - Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TexasMark A Canfield - Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TexasSuzan L Carmichael - Department of Pediatrics, Stanford University, Stanford, CaliforniaNational Birth Defects Prevention Study
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- Birth defects research. A Clinical and molecular teratology, Vol.94(12), pp.1026-1032
- DOI
- 10.1002/bdra.23053
- PMID
- 22821770
- NLM abbreviation
- Birth Defects Res A Clin Mol Teratol
- ISSN
- 1542-0752
- eISSN
- 1542-0760
- Publisher
- Wiley
- Number of pages
- 7
- Language
- English
- Date published
- 12/2012
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984214947702771
Metrics
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