Journal article
Association of microtia with maternal obesity and periconceptional folic acid use
American Journal of Medical Genetics Part A, Vol.152A(11), pp.2756-2761
11/2010
DOI: 10.1002/ajmg.a.33694
PMID: 20949601
Abstract
The study objective was to examine the association of microtia with maternal intake of folic-acid-containing supplements and obesity. The study data included deliveries from 1997 to 2005 from the National Birth Defects Prevention Study. Non-syndromic cases of microtia were compared to non-malformed, population-based liveborn control infants, by estimating adjusted odds ratios (AORs) and 95% confidence intervals (CIs) from logistic regression models that included maternal race/ethnicity, education, and study site. Maternal obesity was only weakly associated with microtia. Maternal periconceptional intake of folic-acid-containing vitamin supplements reduced the risk for microtia, but only among non-obese women (OR: 0.63; 95% CI: 0.44–0.91). The reduced risk was stronger when analyses were restricted to isolated cases (OR: 0.51; 95% CI: 0.34–0.77), and it was independent of the level of maternal dietary folate intake. Adjusting for maternal race/ethnicity did not reveal alternative interpretations of this association. This analysis suggests that maternal periconceptional intake of folic-acid-containing supplements may provide protection from microtia for non-obese women.
Details
- Title: Subtitle
- Association of microtia with maternal obesity and periconceptional folic acid use
- Creators
- Chen Ma - California Research Division, March of Dimes Foundation, Oakland, CaliforniaSuzan L Carmichael - California Research Division, March of Dimes Foundation, Oakland, CaliforniaAngela E Scheuerle - Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TexasMark A Canfield - Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TexasGary M Shaw - Stanford University School of Medicine, Palo Alto, CaliforniaNational Birth Defects Prevention Study
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- American Journal of Medical Genetics Part A, Vol.152A(11), pp.2756-2761
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- DOI
- 10.1002/ajmg.a.33694
- PMID
- 20949601
- ISSN
- 1552-4825
- eISSN
- 1096-8628
- Number of pages
- 6
- Language
- English
- Date published
- 11/2010
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984214815002771
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