Association of multiple sclerosis with risk of mortality among a nationally representative sample of adults in the United States

Tyler J Titcomb; Wei Bao; Yang Du; Buyun Liu; Linda G Snetselaar; Terry L Wahls

doi:10.1177/20552173221104009

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Association of multiple sclerosis with risk of mortality among a nationally representative sample of adults in the United States

Journal article

Open access

Association of multiple sclerosis with risk of mortality among a nationally representative sample of adults in the United States

Tyler J Titcomb, Wei Bao, Yang Du, Buyun Liu, Linda G Snetselaar and Terry L Wahls

Multiple sclerosis journal - experimental, translational and clinical, Vol.8(2), pp.20552173221104009-20552173221104009

04/2022

DOI: 10.1177/20552173221104009

PMCID: PMC9158421

PMID: 35665135

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Abstract

Multiple sclerosis (MS) has been associated with increased mortality ratios, but few studies have investigated the independent association of MS with mortality. To examine the prospective association of MS with risk of mortality in a nationally representative sample of U.S. adults. This prospective study included 23,053 adults aged 45-79 years who participated in the National Health Interview Survey in 2002 and 2008. Physician-diagnosed MS was reported by participants during household interviews. These participants were linked to death records from survey date through December 31, 2015. Among the 23,053 participants included in this study, 120 reported a physician's diagnosis of MS, with a higher prevalence in females (0.85%) than in males (0.31%). During on average 9.4 years (maximum 13.8 years) of observation, 4208 deaths occurred. After adjustment for age, sex, race/ethnicity, socioeconomic factors, lifestyle factors, and BMI, participants with MS had an 80% higher risk of mortality (HR 1.80; 95% CI, 1.11-2.92), compared with those without MS. The association remained significant (HR 1.75; 95% CI, 1.07-2.87) after further adjustment for baseline diabetes, cardiovascular disease, chronic lung disease, and cancer. In this nationally representative sample of U.S. adults, MS was associated with an increased risk of mortality.

Epidemiology

Multiple Sclerosis

mortality

Details

Title: Subtitle: Association of multiple sclerosis with risk of mortality among a nationally representative sample of adults in the United States
Creators: Tyler J Titcomb - Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
Wei Bao - Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China
Yang Du - University of Iowa
Buyun Liu - Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China
Linda G Snetselaar - University of Iowa
Terry L Wahls - University of Iowa
Resource Type: Journal article
Publication Details: Multiple sclerosis journal - experimental, translational and clinical, Vol.8(2), pp.20552173221104009-20552173221104009
DOI: 10.1177/20552173221104009
PMID: 35665135
PMCID: PMC9158421
NLM abbreviation: Mult Scler J Exp Transl Clin
ISSN: 2055-2173
eISSN: 2055-2173
Grant note: DOI: 10.13039/100000062, name: National Institute of Diabetes and Digestive and Kidney Diseases, award: T32DK112751-01
Language: English
Date published: 04/2022
Academic Unit: Neurology; Epidemiology; Fraternal Order of Eagles Diabetes Research Center; General Internal Medicine; Internal Medicine
Record Identifier: 9984267657802771

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