Association of newborn screening metabolites with risk of wheezing in childhood

Brittney M Donovan; Kelli K Ryckman; Patrick J Breheny; Tebeb Gebretsadik; Kedir N Turi; Emma K Larkin; Yinmei Li; Mary C Dorley; Tina V Hartert

doi:10.1038/s41390-018-0070-4

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Association of newborn screening metabolites with risk of wheezing in childhood

Journal article

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Peer reviewed

Association of newborn screening metabolites with risk of wheezing in childhood

Brittney M Donovan, Kelli K Ryckman, Patrick J Breheny, Tebeb Gebretsadik, Kedir N Turi, Emma K Larkin, Yinmei Li, Mary C Dorley and Tina V Hartert

Pediatric research, Vol.84(5), pp.619-624

11/2018

DOI: 10.1038/s41390-018-0070-4

PMCID: PMC6274622

PMID: 29892036

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Abstract

There are critical gaps in our understanding of the temporal relationships between metabolites and subsequent asthma development. This is the first study to examine metabolites from newborn screening in the etiology of early childhood wheezing. One thousand nine hundred and fifty one infants enrolled between 2012 and 2014 from pediatric practices located in Middle Tennessee in the population-based birth cohort study, the Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure Study (INSPIRE), were linked with metabolite data from the Tennessee Newborn Screening Program. The association between the levels of 37 metabolites and the number of wheezing episodes in the past 12 months was assessed at 1, 2, and 3 years of life. Several metabolites were significantly associated with the number of wheezing episodes. Two acylcarnitines, C10:1 and C18:2, showed robust associations. Increasing levels of C10:1 were associated with increasing number of wheezing episodes at 2 years (OR 2.11, 95% CI 1.41-3.17) and 3 years (OR 2.56, 95% CI 1.59-4.11), while increasing levels of C18:2 were associated with increasing number of wheezing episodes at 1 year (OR 1.38, 95% CI 1.12-1.71) and 2 years (OR 1.47, 95% CI 1.17-1.84). Identification of specific metabolites and associated pathways involved in wheezing pathogenesis offer insights into potential targets to prevent childhood asthma morbidity.

Details

Title: Subtitle: Association of newborn screening metabolites with risk of wheezing in childhood
Creators: Brittney M Donovan - Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA
Kelli K Ryckman - Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA
Patrick J Breheny - Department of Biostatistics, University of Iowa College of Public Health, Iowa City, IA, USA
Tebeb Gebretsadik - Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA
Kedir N Turi - Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Emma K Larkin - Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Yinmei Li - Tennessee Department of Health
Mary C Dorley - Division of Laboratory Services, Tennessee Department of Health, Nashville, TN, USA
Tina V Hartert - Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. tina.hartert@vanderbilt.edu
Resource Type: Journal article
Publication Details: Pediatric research, Vol.84(5), pp.619-624
Publisher: United States
DOI: 10.1038/s41390-018-0070-4
PMID: 29892036
PMCID: PMC6274622
ISSN: 1530-0447
eISSN: 1530-0447
Grant note: K24 AI077930 / NIAID NIH HHS R21 HD087864 / NICHD NIH HHS U19 AI095227 / NIAID NIH HHS
Language: English
Date published: 11/2018
Academic Unit: Stead Family Department of Pediatrics; Epidemiology; Biostatistics
Record Identifier: 9983995060802771

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