Association of nutritional status with the response to infection with Leishmania chagasi

Bruna L Lima Maciel; Hênio G Lacerda; José W Queiroz; Juliana Galvão; Núbia N Pontes; Roberto Dimenstein; Stephen E McGowan; Lúcia F C Pedrosa; Selma M B Jerônimo

doi:10.4269/ajtmh.2008.79.591

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Association of nutritional status with the response to infection with Leishmania chagasi

Journal article

Open access

Peer reviewed

Association of nutritional status with the response to infection with Leishmania chagasi

Bruna L Lima Maciel, Hênio G Lacerda, José W Queiroz, Juliana Galvão, Núbia N Pontes, Roberto Dimenstein, Stephen E McGowan, Lúcia F C Pedrosa and Selma M B Jerônimo

The American journal of tropical medicine and hygiene, Vol.79(4), pp.591-598

10/2008

DOI: 10.4269/ajtmh.2008.79.591

PMID: 18840750

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https://www.ajtmh.org/view/journals/tpmd/79/4/article-p591.xml?rskey=4J8J3i&result=1View

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Abstract

Outcomes of infection with Leishmania chagasi range from self-resolving infection to visceral leishmaniasis (VL). Risk factors determining development of disease are not totally understood, but probably include environmental influences and host genetics. We assessed whether nutrition influenced the outcome of Leishmania infection by comparing relatives of children with VL with either self-resolving Leishmania spp. infection or apparently uninfected households. We observed a decrease in body mass index (P < 0.0005) and mid-upper arm circumference for age (P = 0.022) z-scores for children with VL. Levels of vitamin A were lower in active children with VL as measured by serum retinol (P = 0.035) and the modified-relative-dose-response test (P = 0.009). Higher birth weight (P = 0.047) and albumin concentrations (P = 0.040) protected against disease. Increased breastfeeding time (P = 0.036) was associated with asymptomatic infection. The results indicate that modifiable nutritional aspects are associated with the outcome of Leishmania spp. infection in humans.

Breast Feeding

Body Mass Index

Leishmania infantum

Age Factors

Humans

Child, Preschool

Leishmaniasis, Visceral - etiology

Logistic Models

Male

Leishmaniasis, Visceral - immunology

Birth Weight

Animals

Adolescent

Female

Nutritional Status

Child

Vitamin A - blood

Details

Title: Subtitle: Association of nutritional status with the response to infection with Leishmania chagasi
Creators: Bruna L Lima Maciel - Health Sciences Post-Graduate Program, Health Science Center, and Department of Biochemistry, Bioscience Center, Federal University of Rio Grande do Norte, Natal, Brazil. smbj@cb.ufrn.br
Hênio G Lacerda
José W Queiroz
Juliana Galvão
Núbia N Pontes
Roberto Dimenstein
Stephen E McGowan
Lúcia F C Pedrosa
Selma M B Jerônimo
Resource Type: Journal article
Publication Details: The American journal of tropical medicine and hygiene, Vol.79(4), pp.591-598
DOI: 10.4269/ajtmh.2008.79.591
PMID: 18840750
NLM abbreviation: Am J Trop Med Hyg
ISSN: 0002-9637
eISSN: 1476-1645
Publisher: United States
Grant note: R03 TW001297 / FIC NIH HHS AI030639-15S1 / NIAID NIH HHS
Language: English
Date published: 10/2008
Academic Unit: International Programs; Internal Medicine
Record Identifier: 9983983666602771

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