Journal article
Association of pharmacologic treatment of urgency urinary incontinence with sleep quality and daytime sleepiness
Obstetrics and Gynecology, Vol.131(2), pp.204-211
2018
DOI: 10.1097/AOG.0000000000002443
PMID: 29324595
Abstract
OBJECTIVE: To evaluate the association between pharmacologic therapy for urgency urinary incontinence (UUI) and sleep quality.METHODS: We conducted a planned secondary data analysis of sleep outcomes in a previously conducted multicenter, double-blind, 12-week randomized trial of pharmacologic therapy for urgency-predominant incontinence among community-dwelling women self-diagnosed using the 3-Incontinence Questions questionnaire. Participants (N=645) were assigned randomly to 4-8 mg antimuscarinic therapy daily or placebo. At baseline and 12 weeks, participants completed a validated voiding diary to evaluate incontinence and voiding symptoms, the Pittsburgh Sleep Quality Index to evaluate sleep quality, and the Epworth Sleepiness Scale to evaluate daytime sleepiness.RESULTS: Mean (SD) age was 56 (±14) years, 68% were white, and 57% had poor sleep quality (Pittsburgh Sleep Quality Index score greater than 5). Mean frequency of any urinary incontinence and UUI was 4.6 and 3.9 episodes/d, respectively. After 12 weeks, women randomized to the antimuscarinic group reported greater decrease compared with the placebo group in UUI frequency (0.9 episodes/d; P<.001) and diurnal and nocturnal voiding frequency (P<.05). As compared with the placebo group, women in the antimuscarinic group also reported greater improvement in sleep quality (total Pittsburgh Sleep Quality Index score 0.48; P=.02) with greater improvement in sleep duration and sleep efficiency subscales (P<.05). The intervention did not affect daytime sleepiness.CONCLUSION: Pharmacologic treatment of UUI is associated with decreased incontinence frequency and nocturia and improvement in overall sleep quality, sleep duration, and sleep efficiency.CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, NCT00862745.
Details
- Title: Subtitle
- Association of pharmacologic treatment of urgency urinary incontinence with sleep quality and daytime sleepiness
- Creators
- Qurratul A WarsiAlison J HuangRachel HessLily A AryaHolly E RichterCatherine S BradleyRebecca G RogersDeborah L MyersKaren C JohnsonWilliam D WinkelmanW Thomas GregoryStephen R KrausMichael SchembriJeanette S BrownKatie L StoneLeslee L Subak
- Resource Type
- Journal article
- Publication Details
- Obstetrics and Gynecology, Vol.131(2), pp.204-211
- DOI
- 10.1097/AOG.0000000000002443
- PMID
- 29324595
- NLM abbreviation
- Obstet Gynecol
- ISSN
- 1873-233X
- eISSN
- 1873-233X
- Language
- English
- Date published
- 2018
- Academic Unit
- Epidemiology; Obstetrics and Gynecology; Urology
- Record Identifier
- 9983931817202771
Metrics
37 Record Views