Journal article
Association of plasma beta-amyloid 40 and 42 concentration with type 2 diabetes among Chinese adults
Diabetologia, Vol.63(5), pp.954-963
05/01/2020
DOI: 10.1007/s00125-020-05102-x
PMID: 32034441
Abstract
Aims/hypothesis There is evidence for a bidirectional association between type 2 diabetes and Alzheimer's disease. Plasma beta-amyloid (A beta) is a potential biomarker for Alzheimer's disease. We aimed to investigate the association of plasma A beta 40 and A beta 42 with risk of type 2 diabetes. Methods We performed a case-control study and a nested case-control study within a prospective cohort study. In the case-control study, we included 1063 newly diagnosed individuals with type 2 diabetes and 1063 control participants matched by age (+/- 3 years) and sex. In the nested case-control study, we included 121 individuals with incident type 2 diabetes and 242 matched control individuals. Plasma A beta 40 and A beta 42 concentrations were simultaneously measured with electrochemiluminescence immunoassay. Conditional logistic regression was used to evaluate the association of plasma A beta 40 and A beta 42 concentrations with the likelihood of type 2 diabetes. Results In the case-control study, the multivariable-adjusted ORs for type 2 diabetes, comparing the highest with the lowest quartile of plasma A beta concentrations, were 1.97 (95% CI 1.46, 2.66) for plasma A beta 40 and 2.01 (95% CI 1.50, 2.69) for plasma A beta 42. Each 30 ng/l increment of plasma A beta 40 was associated with 28% (95% CI 15%, 43%) higher odds of type 2 diabetes, and each 5 ng/l increment of plasma A beta 42 was associated with 37% (95% CI 21%, 55%) higher odds of type 2 diabetes. Individuals in the highest tertile for both plasma A beta 40 and A beta 42 concentrations had 2.96-fold greater odds of type 2 diabetes compared with those in the lowest tertile for both plasma A beta 40 and A beta 42 concentrations. In the nested case-control study, the multivariable-adjusted ORs for type 2 diabetes for the highest vs the lowest quartile were 3.79 (95% CI 1.81, 7.94) for plasma A beta 40 and 2.88 (95% CI 1.44, 5.75) for plasma A beta 42. The multivariable-adjusted ORs for type 2 diabetes associated with each 30 ng/l increment in plasma A beta 40 and each 5 ng/l increment in plasma A beta 42 were 1.44 (95% CI 1.18, 1.74) and 1.47 (95% CI 1.15, 1.88), respectively. Conclusions/interpretation Our findings suggest positive associations of plasma A beta 40 and A beta 42 concentration with risk of type 2 diabetes. Further studies are warranted to elucidate the underlying mechanisms and explore the potential roles of plasma A beta in linking type 2 diabetes and Alzheimer's disease.
Details
- Title: Subtitle
- Association of plasma beta-amyloid 40 and 42 concentration with type 2 diabetes among Chinese adults
- Creators
- Xiaobo Peng - Huazhong University of Science and TechnologyZihui Xu - Huazhong University of Science and TechnologyXiaoxing Mo - Huazhong University of Science and TechnologyQianqian Guo - Huazhong University of Science and TechnologyJiawei Yin - Huazhong University of Science and TechnologyMengdai Xu - Huazhong University of Science and TechnologyZhao Peng - Huazhong University of Science and TechnologyTaoping Sun - Huazhong University of Science and TechnologyLi Zhou - Huazhong University of Science and TechnologyXiaolin Peng - Huazhong University of Science and TechnologyShufang Xu - Huazhong University of Science and TechnologyWei Yang - Huazhong University of Science and TechnologyWei Bao - University of IowaZhilei Shan - Huazhong University of Science and TechnologyXiaoqin Li - Huazhong University of Science and TechnologyLiegang Liu - Huazhong University of Science and Technology
- Resource Type
- Journal article
- Publication Details
- Diabetologia, Vol.63(5), pp.954-963
- Publisher
- Springer Nature
- DOI
- 10.1007/s00125-020-05102-x
- PMID
- 32034441
- ISSN
- 0012-186X
- eISSN
- 1432-0428
- Number of pages
- 10
- Grant note
- NSFC 81820108027 / Major International (Regional) Joint Research Project 2017YFC1600500 / National Key Research and Development Program of China 81773423; 21537001 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC)
- Language
- English
- Date published
- 05/01/2020
- Academic Unit
- Epidemiology
- Record Identifier
- 9984364656602771
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