Association of plasma human immunodeficiency virus type-1 RNA level with risk of clinical progression in patients with advanced infection

R. W COOMBS; S. L WELLES; J TODD; J. B JACKSON; V DEGRUTTOLA; C. S CRUMPACKER; J KAHN; C HOOPER; P. S REICHELDERFER; R. T D'AQUILA; A. J JAPOUR; V. A JOHNSON; D. R KURITZKES; D. D RICHMAN; S KWOK

doi:10.1093/infdis/174.4.704

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Association of plasma human immunodeficiency virus type-1 RNA level with risk of clinical progression in patients with advanced infection

Journal article

Open access

Peer reviewed

Association of plasma human immunodeficiency virus type-1 RNA level with risk of clinical progression in patients with advanced infection

R. W COOMBS, S. L WELLES, J TODD, J. B JACKSON, V DEGRUTTOLA, C. S CRUMPACKER, J KAHN, C HOOPER, P. S REICHELDERFER, R. T D'AQUILA, …

The Journal of infectious diseases, Vol.174(4), pp.704-712

1996

DOI: 10.1093/infdis/174.4.704

PMID: 8843206

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Abstract

Human immunodeficiency virus (HIV)-1 RNA level in plasma was evaluated as a surrogate marker for disease progression in a clinical trial of advanced HIV-1 infection. Baseline HIV-l RNA level was an independent predictor of disease progression (relative hazard [RH] for each doubling of HIV-1 RNA level, 1.26; 95% confidence interval [CI], 1.03-1.54; P = .02), after adjusting for the week 4 change in HIV-1 RNA level, baseline CD4 cell count, syncytium-inducing phenotype, clinical status at study entry, and therapy randomization. A 50% reduction in HIV-1 RNA level was associated with a 27% decrease in the adjusted risk of disease progression during the study (RH, 0.73; 95% CI, 0.52-1.02; P = .07). The partial validation ofHIV-1 RNA as a predictor for clinical end points has implications for the use of HIV-1 RNA in clinical trials and practice.

Immunopathology

Biological and medical sciences

Medical sciences

Immunodeficiencies. Immunoglobulinopathies

Immunodeficiencies

Details

Title: Subtitle: Association of plasma human immunodeficiency virus type-1 RNA level with risk of clinical progression in patients with advanced infection
Creators: R. W COOMBS - Birmingham VA Medical Center, Birmingham, Alabama, United States
S. L WELLES - Birmingham VA Medical Center, Birmingham, Alabama, United States
J TODD - Birmingham VA Medical Center, Birmingham, Alabama, United States
J. B JACKSON - Birmingham VA Medical Center, Birmingham, Alabama, United States
V DEGRUTTOLA - Birmingham VA Medical Center, Birmingham, Alabama, United States
C. S CRUMPACKER - Birmingham VA Medical Center, Birmingham, Alabama, United States
J KAHN - Birmingham VA Medical Center, Birmingham, Alabama, United States
C HOOPER - Birmingham VA Medical Center, Birmingham, Alabama, United States
P. S REICHELDERFER - Birmingham VA Medical Center, Birmingham, Alabama, United States
R. T D'AQUILA - Birmingham VA Medical Center, Birmingham, Alabama, United States
A. J JAPOUR - Birmingham VA Medical Center, Birmingham, Alabama, United States
V. A JOHNSON - Birmingham VA Medical Center, Birmingham, Alabama, United States
D. R KURITZKES - Birmingham VA Medical Center, Birmingham, Alabama, United States
D. D RICHMAN - Birmingham VA Medical Center, Birmingham, Alabama, United States
S KWOK - Birmingham VA Medical Center, Birmingham, Alabama, United States
Resource Type: Journal article
Publication Details: The Journal of infectious diseases, Vol.174(4), pp.704-712
Publisher: University of Chicago Press; Chicago, IL
DOI: 10.1093/infdis/174.4.704
PMID: 8843206
ISSN: 0022-1899
eISSN: 1537-6613
Language: English
Date published: 1996
Academic Unit: Pathology; VPMA - Administration
Record Identifier: 9984047719502771

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