Association of prion protein expression with pancreatic adenocarcinoma survival in the SEER residual tissue repository

Man-Sun Sy; Sean F Altekruse; Chaoyang Li; Charles F Lynch; Marc T Goodman; Brenda Y Hernandez; Lan Zhou; Maria Sibug Saber; Stephen M Hewitt; Wei Xin

doi:10.3233/CBM-2012-0256

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Association of prion protein expression with pancreatic adenocarcinoma survival in the SEER residual tissue repository

Journal article

Open access

Peer reviewed

Association of prion protein expression with pancreatic adenocarcinoma survival in the SEER residual tissue repository

Man-Sun Sy, Sean F Altekruse, Chaoyang Li, Charles F Lynch, Marc T Goodman, Brenda Y Hernandez, Lan Zhou, Maria Sibug Saber, Stephen M Hewitt and Wei Xin

Cancer biomarkers : section A of Disease markers, Vol.10(6), pp.251-258

2011

DOI: 10.3233/CBM-2012-0256

PMCID: PMC5008856

PMID: 22820080

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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an important cause of cancer death with no clear prognostic biomarker. Expression of prion (PrP) has been reported to be a marker of poor prognosis in a series of Caucasian PDAC cases. We determined the prognostic value of PrP in a racially and geographically diverse population-based series of PDAC cases. PrP expression was examined in 142 PDAC cases from three cancer registries. Cases included 71 Caucasian, 54 Asian/Pacific Islanders and 17 Blacks diagnosed from 1983-2000, and followed through 2008. Hazard ratios (HR) and 95% confidence intervals (CIs) for the association of PrP expression with survival were computed after adjustment for case attributes. The risk of death was about four times higher (HR=3.8; 95% PDAC cases with PrP(+) tumors (median survival 5 months) compared to the 34 cases with PrP(-) tumors (median survival 20 months). Of 51 cases with resected, localized PDAC median survival was 74 months for 17 cases with PrP(-) tumors versus 14 months for 34 cases with PrP(+) tumors (HR=6.7; 95% CI: 2.6, 17.4). All 6 surviving cases had PrP(-) negative tumors (median survival, > 10 years). PrP may have potential as a prognostic biomarker in PDAC patient management.

Prions - metabolism

Tissue Banks

SEER Program

Adenocarcinoma - pathology

Pancreatic Neoplasms - metabolism

Prognosis

Tissue Array Analysis

Humans

Middle Aged

Pancreatic Neoplasms - pathology

Kaplan-Meier Estimate

Proportional Hazards Models

Male

Adenocarcinoma - metabolism

Aged, 80 and over

Biomarkers, Tumor - metabolism

Female

Aged

Pancreatic Neoplasms - mortality

Adenocarcinoma - mortality

Cohort Studies

Details

Title: Subtitle: Association of prion protein expression with pancreatic adenocarcinoma survival in the SEER residual tissue repository
Creators: Man-Sun Sy - Department of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA
Sean F Altekruse
Chaoyang Li - Case Western Reserve University
Charles F Lynch
Marc T Goodman
Brenda Y Hernandez
Lan Zhou - Case Western Reserve University
Maria Sibug Saber
Stephen M Hewitt
Wei Xin
Resource Type: Journal article
Publication Details: Cancer biomarkers : section A of Disease markers, Vol.10(6), pp.251-258
Publisher: Netherlands
DOI: 10.3233/CBM-2012-0256
PMID: 22820080
PMCID: PMC5008856
ISSN: 1574-0153
eISSN: 1875-8592
Grant note: N01 PC035139 / NCI NIH HHS R21CA133559-01 / NCI NIH HHS R21 CA133559 / NCI NIH HHS Intramural NIH HHS N01PC35143 / NCI NIH HHS N01-PC-35137 / NCI NIH HHS N01-PC-35139 / NCI NIH HHS N01PC35139 / NCI NIH HHS N01 PC035137 / NCI NIH HHS N01PC35137 / NCI NIH HHS N01-PC-35143 / NCI NIH HHS
Language: English
Date published: 2011
Academic Unit: Epidemiology
Record Identifier: 9983996072702771

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