Journal article
Association of the Skn7 and Yap1 transcription factors in the Saccharomyces cerevisiae oxidative stress response
Eukaryotic cell, Vol.10(6), pp.761-769
06/2011
DOI: 10.1128/EC.00328-10
PMCID: PMC3127664
PMID: 21478431
Abstract
Saccharomyces cerevisiae Skn7p is a stress response transcription factor that undergoes aspartyl phosphorylation by the Sln1p histidine kinase. Aspartyl phosphorylation of Skn7p is required for activation of genes required in response to wall stress, but Skn7p also activates oxidative stress response genes in an aspartyl phosphorylation-independent manner. The presence of binding sites for the Yap1p and Skn7p transcription factors in oxidative stress response promoters and the oxidative stress-sensitive phenotypes of SKN7 and YAP1 mutants suggest that these two factors work together. We present here evidence for a DNA-independent interaction between the Skn7 and Yap1 proteins that involves the receiver domain of Skn7p and the cysteine-rich domains of Yap1p. The interaction with Yap1p may help partition the Skn7 protein to oxidative stress response promoters when the Yap1 protein accumulates in the nucleus.
Details
- Title: Subtitle
- Association of the Skn7 and Yap1 transcription factors in the Saccharomyces cerevisiae oxidative stress response
- Creators
- K E Mulford - Department of Biology, University of Iowa, 202 BBE, Iowa City, IA 52242, USAJ S Fassler
- Resource Type
- Journal article
- Publication Details
- Eukaryotic cell, Vol.10(6), pp.761-769
- DOI
- 10.1128/EC.00328-10
- PMID
- 21478431
- PMCID
- PMC3127664
- NLM abbreviation
- Eukaryot Cell
- ISSN
- 1535-9778
- eISSN
- 1535-9786
- Publisher
- American Society for Microbiology; United States
- Grant note
- R01 GM068746 / NIGMS NIH HHS R01 GM056719 / NIGMS NIH HHS GM056719 / NIGMS NIH HHS GM068746 / NIGMS NIH HHS
- Language
- English
- Date published
- 06/2011
- Academic Unit
- Biology
- Record Identifier
- 9983992080702771
Metrics
35 Record Views