Journal article
Association of the membrane estrogen receptor, GPR30, with breast tumor metastasis and transactivation of the epidermal growth factor receptor
Steroids, Vol.73(9), pp.870-873
2008
DOI: 10.1016/j.steroids.2007.12.025
PMID: 18289622
Abstract
The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases function as a common signaling conduit for membrane receptors that lack intrinsic enzymatic activity, such as G-protein coupled receptors and integrins. GPR30, an orphan member of the seven transmembrane receptor (7TMR) superfamily has been linked to specific estrogen binding, rapid estrogen-mediated activation of adenylyl cyclase and the release of membrane-tethered proHB-EGF. More recently, GPR30 expression in primary breast adenocarcinoma has been associated with pathological parameters commonly used to assess breast cancer progression, including the development of extramammary metastases. This newly appreciated mechanism of cross communication between estrogen and EGF is consistent with the observation that 7TMR-mediated transactivation of the EGFR is a recurrent signaling paradigm and may explain prior data reporting the EGF-like effects of estrogen. The molecular details surrounding GPR30-mediated release of proHB-EGF, the involvement of integrin β1 as a signaling intermediary in estrogen-dependent EGFR action, and the possible implications of these data for breast cancer progression are discussed herein.
Details
- Title: Subtitle
- Association of the membrane estrogen receptor, GPR30, with breast tumor metastasis and transactivation of the epidermal growth factor receptor
- Creators
- Edward J Filardo - Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence, RI 02903, USAJeffrey A Quinn - Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence, RI 02903, USAEdmond Sabo - Department of Pathology, Rhode Island Hospital and Brown University School of Medicine, Providence, RI 02903, USA
- Resource Type
- Journal article
- Publication Details
- Steroids, Vol.73(9), pp.870-873
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.steroids.2007.12.025
- PMID
- 18289622
- ISSN
- 0039-128X
- eISSN
- 1878-5867
- Language
- English
- Date published
- 2008
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Surgery; Internal Medicine
- Record Identifier
- 9984051595302771
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