Journal article
Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults
JAMA : the journal of the American Medical Association, Vol.300(11), pp.1303-1310
09/17/2008
DOI: 10.1001/jama.300.11.1303
PMID: 18799442
Abstract
Context Bisphenol A ( BPA) is widely used in epoxy resins lining food and beverage containers. Evidence of effects in animals has generated concern over low- level chronic exposures in humans.
Objective To examine associations between urinary BPA concentrations and adult health status.
Design, Setting, and Participants Cross- sectional analysis of BPA concentrations and health status in the general adult population of the United States, using data from the National Health and Nutrition Examination Survey 2003- 2004. Participants were 1455 adults aged 18 through 74 years with measured urinary BPA and urine creatinine concentrations. Regression models were adjusted for age, sex, race/ ethnicity, education, income, smoking, body mass index, waist circumference, and urinary creatinine concentration. The sample provided 80% power to detect unadjusted odds ratios ( ORs) of 1.4 for diagnoses of 5% prevalence per 1- SD change in BPA concentration, or standardized regression coefficients of 0.075 for liver enzyme concentrations, at a significance level of P <. 05.
Main Outcome Measures Chronic disease diagnoses plus blood markers of liver function, glucose homeostasis, inflammation, and lipid changes.
Results Higher urinary BPA concentrations were associated with cardiovascular diagnoses in age-, sex-, and fully adjusted models ( OR per 1- SD increase in BPA concentration, 1.39; 95% confidence interval [ CI], 1.18- 1.63; P=. 001 with full adjustment). Higher BPA concentrations were also associated with diabetes ( OR per 1- SD increase in BPA concentration, 1.39; 95% confidence interval [ CI], 1.21- 1.60; P <. 001) but not with other studied common diseases. In addition, higher BPA concentrations were associated with clinically abnormal concentrations of the liver enzymes gamma- glutamyltransferase ( OR per 1- SD increase in BPA concentration, 1.29; 95% CI, 1.14- 1.46; P <. 001) and alkaline phosphatase ( OR per 1- SD increase in BPA concentration, 1.48; 95% CI, 1.18- 1.85; P=. 002).
Conclusion Higher BPA exposure, reflected in higher urinary concentrations of BPA, may be associated with avoidable morbidity in the community- dwelling adult population.
Details
- Title: Subtitle
- Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults
- Creators
- Iain A. Lang - Health and Safety ExecutiveTamara S. Galloway - Peninsula College of Medicine and DentistryAlan Scarlett - Peninsula College of Medicine and DentistryWilliam E. Henley - University of PlymouthMichael Depledge - Phillips Exeter AcademyRobert B. Wallace - University of IowaDavid Melzer - Phillips Exeter Academy
- Resource Type
- Journal article
- Publication Details
- JAMA : the journal of the American Medical Association, Vol.300(11), pp.1303-1310
- DOI
- 10.1001/jama.300.11.1303
- PMID
- 18799442
- NLM abbreviation
- JAMA
- ISSN
- 0098-7484
- eISSN
- 1538-3598
- Publisher
- Amer Medical Assoc
- Number of pages
- 8
- Grant note
- United Kingdom National Health Service South West Region Public Health Training Scheme
- Language
- English
- Date published
- 09/17/2008
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363665002771
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