Journal article
Association of urinary levels of bisphenols F and S used as bisphenol A substitutes with asthma and hay fever outcomes
Environmental research, Vol.183, pp.108944-108944
04/2020
DOI: 10.1016/j.envres.2019.108944
PMID: 31911000
Abstract
Bisphenols F (BPF) and S (BPS) are bisphenol A (BPA) analogs used as substitutes in consumer products. Despite previous reports of BPA's association with asthma, no studies have examined its structural analogs in relation to asthma and allergy outcomes.
To examine the association of urinary BPF, BPS, and BPA with asthma and hay fever in a US representative sample.
We analyzed data from 3,538 participants aged 12 years or older in the 2013–2016 National Health and Nutrition Examination Survey (NHANES). Children aged 6–11 years (N = 738), who did not have all covariate data available, were analyzed separately. Covariate-adjusted logistic regression was used to assess the association of the exposures with the outcomes.
BPF, BPS, and BPA were detected in 57.1%, 88.4%, and 94.8% of the urine samples, respectively. Urinary BPF detection was positively associated with current asthma (odds ratio [OR]: 1.54, 95% confidence interval [CI]: 1.16–2.04) and hay fever (OR: 1.66, 95% CI: 1.12–2.46). Urinary BPS was associated with increased odds of current asthma in men (OR: 1.64, 95% CI: 1.13–2.40) and urinary BPA was associated with increased odds of asthma without hay fever in children aged 6–11 years (OR: 2.65, 95% CI: 1.05–6.68).
Our nationally-representative findings document that BPF and BPS exposure is common in the US and that exposure to these BPA analogs is associated with asthma and/or hay fever. Our results suggest that BPF and BPS may not be safe alternatives to BPA; however, prospective studies should be conducted to confirm these results.
•Urinary bisphenol F (BPF) was associated with higher odds of asthma and hay fever.•Urinary bisphenol S (BPS) was associated with higher odds of asthma in men.•Urinary bisphenol A (BPA) was positively associated with asthma without hay fever in children.
Details
- Title: Subtitle
- Association of urinary levels of bisphenols F and S used as bisphenol A substitutes with asthma and hay fever outcomes
- Creators
- Angelico Mendy - Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USAPaïvi M Salo - Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USAJesse Wilkerson - Social & Scientific Systems, Durham, NC, USALydia Feinstein - Social & Scientific Systems, Durham, NC, USAKelly K Ferguson - Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USAMichael B Fessler - Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USAPeter S Thorne - Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, USADarryl C Zeldin - Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
- Resource Type
- Journal article
- Publication Details
- Environmental research, Vol.183, pp.108944-108944
- DOI
- 10.1016/j.envres.2019.108944
- PMID
- 31911000
- NLM abbreviation
- Environ Res
- ISSN
- 0013-9351
- eISSN
- 1096-0953
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100000002, name: NIH; DOI: 10.13039/100000066, name: National Institute of Environmental Health Sciences, award: Z01 ES025041, Z01 ES102005; DOI: 10.13039/100000066, name: National Institute of Environmental Health Sciences, award: HHSN273201600002I
- Language
- English
- Date published
- 04/2020
- Academic Unit
- Civil and Environmental Engineering; Occupational and Environmental Health
- Record Identifier
- 9984000930102771
Metrics
26 Record Views