Association of visual function and ganglion cell layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy

Hille W van Dijk; Frank D Verbraak; Marilette Stehouwer; Pauline H.B Kok; Mona K Garvin; Milan Sonka; J. Hans DeVries; Reinier O Schlingemann; Michael D Abràmoff

doi:10.1016/j.visres.2010.08.024

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Association of visual function and ganglion cell layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy

Journal article

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Association of visual function and ganglion cell layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy

Hille W van Dijk, Frank D Verbraak, Marilette Stehouwer, Pauline H.B Kok, Mona K Garvin, Milan Sonka, J. Hans DeVries, Reinier O Schlingemann and Michael D Abràmoff

Vision Research, Vol.51(2), pp.224-228

2011

DOI: 10.1016/j.visres.2010.08.024

PMCID: PMC3017636

PMID: 20801146

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Abstract

► Diabetic retinopathy includes neurodegeneration. ► Diabetic neurodegeneration is demonstrated by a decreased ganglion cell layer (GCL). ► There exists a linear relation between decreased GCL and visual function loss. Diabetic retinopathy (DR) classically presents with micro-aneurysms, small haemorrhages and/or lipoprotein exudates. Several studies have indicated that neural loss occurs in DR even before vascular damage can be observed. This study evaluated the possible relationship between structure (spectral domain–optical coherence tomography) and function (Rarebit visual field test) in patients with type 1 diabetes mellitus and no or minimal diabetic retinopathy (DR). Results demonstrated loss of macular visual function and corresponding thinning of the ganglion cell layer (GCL) in the pericentral area of the macula of diabetic patients (Rs = 0.65, p < 0.001). In multivariable logistic regression analysis, GCL thickness remained an independent predictor of decreased visual function (OR 1.5, 95% CI 1.1–2.1). Early DR seems to include a neurodegenerative component.

Diabetic Retinopathy

Retina

Visual function

Ganglion cell layer

Diabetic neurodegeneration

Details

Title: Subtitle: Association of visual function and ganglion cell layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy
Creators: Hille W van Dijk - Dept. of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands
Frank D Verbraak - Dept. of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands
Marilette Stehouwer - Dept. of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands
Pauline H.B Kok - Dept. of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands
Mona K Garvin - Dept. of Electrical and Computer Engineering, The University of Iowa, Iowa City, IA, USA
Milan Sonka - Dept. of Electrical and Computer Engineering, The University of Iowa, Iowa City, IA, USA
J. Hans DeVries - Dept. of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
Reinier O Schlingemann - Dept. of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands
Michael D Abràmoff - Dept. of Electrical and Computer Engineering, The University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Vision Research, Vol.51(2), pp.224-228
DOI: 10.1016/j.visres.2010.08.024
PMID: 20801146
PMCID: PMC3017636
NLM abbreviation: Vision Res
ISSN: 0042-6989
eISSN: 1878-5646
Publisher: Elsevier Ltd
Language: English
Date published: 2011
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; Injury Prevention Research Center; Ophthalmology and Visual Sciences
Record Identifier: 9983806367102771

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