Association study of serotonin pathway genes in attempted suicide

Jennifer T Judy; Fayaz Seifuddin; Pamela B Mahon; Yuqing Huo; Fernando S Goes; Dubravka Jancic; Barbara Schweizer; Francis M Mondimore; Dean F Mackinnon; J Raymond Depaulo Jr; Elliot S Gershon; Francis J McMahon; Peter P Zandi; David J Cutler; James B Potash; Virginia L Willour

doi:10.1002/ajmg.b.32008

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Association study of serotonin pathway genes in attempted suicide

Journal article

Peer reviewed

Association study of serotonin pathway genes in attempted suicide

Jennifer T Judy, Fayaz Seifuddin, Pamela B Mahon, Yuqing Huo, Fernando S Goes, Dubravka Jancic, Barbara Schweizer, Francis M Mondimore, Dean F Mackinnon, J Raymond Depaulo Jr, …

American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.159B(1), pp.112-119

01/2012

DOI: 10.1002/ajmg.b.32008

PMCID: PMC4021704

PMID: 22170779

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https://www.ncbi.nlm.nih.gov/pmc/articles/4021704View

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Abstract

Epidemiological studies, such as family, twin, and adoption studies, demonstrate the presence of a heritable component to both attempted and completed suicide. Some of this heritability is accounted for by the presence of comorbid psychiatric disorders, but the evidence also indicates that a portion of this heritability is specific to suicidality. The serotonergic system has been studied extensively in this phenotype, but findings have been inconsistent, possibly due to the presence of multiple susceptibility variants and/or gene-gene interactions. In this study, we genotyped 174 tag and coding single nucleotide polymorphisms (SNPs) from 17 genes within the serotonin pathway on 516 subjects with a major mood disorder and a history of a suicide attempt (cases) and 515 healthy controls, with the goal of capturing the common genetic variation across each of these candidate genes. We tested the 174 markers in single-SNP, haplotype, gene-based, and epistasis analyses. While these association analyses identified multiple marginally significant SNPs, haplotypes, genes, and interactions, none of them survived correction for multiple testing. Additional studies, including assessment in larger sample sets and deep resequencing to identify rare causal variants, may be required to fully understand the role that the serotonin pathway plays in suicidal behavior.

Suicide, Attempted - psychology

Genetic Association Studies

Serotonin - genetics

Synaptic Transmission - genetics

Humans

Polymorphism, Single Nucleotide - genetics

Signal Transduction - genetics

Details

Title: Subtitle: Association study of serotonin pathway genes in attempted suicide
Creators: Jennifer T Judy - Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Fayaz Seifuddin
Pamela B Mahon
Yuqing Huo
Fernando S Goes
Dubravka Jancic
Barbara Schweizer
Francis M Mondimore
Dean F Mackinnon
J Raymond Depaulo Jr
Elliot S Gershon
Francis J McMahon
Peter P Zandi
David J Cutler
James B Potash
Virginia L Willour
Resource Type: Journal article
Publication Details: American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.159B(1), pp.112-119
DOI: 10.1002/ajmg.b.32008
PMID: 22170779
PMCID: PMC4021704
NLM abbreviation: Am J Med Genet B Neuropsychiatr Genet
ISSN: 1552-4841
eISSN: 1552-485X
Publisher: United States
Grant note: MH 63420 / NIMH NIH HHS\nR01 MH059535 / NIMH NIH HHS\nMH061675 / NIMH NIH HHS\nR01 MH59553 / NIMH NIH HHS\nU01MH46274 / NIMH NIH HHS\nR01 MH059566 / NIMH NIH HHS\nMH59566 / NIMH NIH HHS\nR01 MH059542 / NIMH NIH HHS\nMH067257 / NIMH NIH HHS\nR01 MH061686 / NIMH NIH HHS\nU01 MH46280 / NIMH NIH HHS\nR01 MH060866 / NIMH NIH HHS\nR01 MH059567 / NIMH NIH HHS\nR01 MH059587 / NIMH NIH HHS\nR01 MH059552 / NIMH NIH HHS\nZ01 MH002810 / Intramural NIH HHS\nR01 MH059541-05 / NIMH NIH HHS\nR01 MH59567 / NIMH NIH HHS\nR01 MH059533 / NIMH NIH HHS\nU01 MH060879 / NIMH NIH HHS\nR01 MH059541 / NIMH NIH HHS\nR01 MH079240 / NIMH NIH HHS\nU01MH46282 / NIMH NIH HHS\nR01 MH059565 / NIMH NIH HHS\nR01 MH59535 / NIMH NIH HHS\nR01 MH059571 / NIMH NIH HHS\nMH59586 / NIMH NIH HHS\nR01 MH063420 / NIMH NIH HHS\nR01 MH060870 / NIMH NIH HHS\nR01 MH061675 / NIMH NIH HHS\nR01 MH60068 / NIMH NIH HHS\nR01 MH067257 / NIMH NIH HHS\nR01 MH060879 / NIMH NIH HHS\nR01 MH060912 / NIMH NIH HHS\nR01 MH059548 / NIMH NIH HHS\nMH059588 / NIMH NIH HHS\nMH079240 / NIMH NIH HHS\nR01MH59545 / NIMH NIH HHS\nR01 MH059586 / NIMH NIH HHS\nR01 MH59533 / NIMH NIH HHS\nMH059565 / NIMH NIH HHS\nR01 MH61686 / NIMH NIH HHS\nMH60870 / NIMH NIH HHS\nR01 MH059556 / NIMH NIH HHS\nMH59587 / NIMH NIH HHS\nR01 MH059545 / NIMH NIH HHS\nR01 MH059534 / NIMH NIH HHS\nR01 MH059588 / NIMH NIH HHS\nR01 MH059553 / NIMH NIH HHS\nR01 MH060068 / NIMH NIH HHS
Language: English
Date published: 01/2012
Academic Unit: Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984070249002771

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