Journal article
Associations Among 25-Hydroxyvitamin D Levels, Lung Function, and Exacerbation Outcomes in COPD
Chest, Vol.157(4), pp.856-865
04/2020
DOI: 10.1016/j.chest.2019.11.047
PMCID: PMC7118244
PMID: 31958447
Abstract
The relationship between 25-hydroxyvitamin D (25-OH-vitamin D) and COPD outcomes remains unclear. Using the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS), we determined associations among baseline 25-OH-vitamin D and cross-sectional and longitudinal lung function and COPD exacerbations.
Serum 25-OH-vitamin D level was measured in stored samples from 1,609 SPIROMICS participants with COPD. 25-OH-vitamin D levels were modeled continuously and dichotomized as deficient (< 20 ng/mL) vs not deficient (≥ 20 ng/mL). Outcomes of interest included % predicted FEV1 (current and 1-year longitudinal decline) and COPD exacerbations (separately any and severe, occurring in prior year and first year of follow-up).
Vitamin D deficiency was present in 21% of the cohort and was more prevalent in the younger, active smokers, and blacks. Vitamin D deficiency was independently associated with lower % predicted FEV1 (by 4.11%) at enrollment (95% CI, –6.90% to –1.34% predicted FEV1; P = .004), 1.27% predicted greater rate of FEV1 decline after 1 year (95% CI, –2.32% to –0.22% predicted/y; P = .02), and higher odds of any COPD exacerbation in the prior year (OR, 1.32; 95% CI, 1.00-1.74; P = .049). Each 10-ng/mL decrease in 25-OH-vitamin D was associated with lower baseline lung function (–1.04% predicted; 95% CI, –1.96% to –0.12% predicted; P = .03) and increased odds of any exacerbation in the year before enrollment (OR, 1.11; 95% CI, 1.01-1.22; P = .04).
Vitamin D deficiency is associated with worse cross-sectional and longitudinal lung function and increased odds of prior COPD exacerbations. These findings identify 25-OH-vitamin D levels as a potentially useful marker of adverse COPD-related outcomes.
Details
- Title: Subtitle
- Associations Among 25-Hydroxyvitamin D Levels, Lung Function, and Exacerbation Outcomes in COPD
- Creators
- Robert M. Burkes - University of North Carolina at Chapel HillAgathe S. Ceppe - University of North Carolina at Chapel HillClaire M. Doerschuk - University of North Carolina at Chapel HillDavid Couper - University of North Carolina at Chapel HillEric A. Hoffman - University of IowaAlejandro P. Comellas - University of IowaR. Graham Barr - Columbia UniversityJerry A. Krishnan - University of Illinois ChicagoChristopher Cooper - University of California, Los AngelesWassim W. Labaki - University of MichiganVictor E. Ortega - Wake Forest UniversityJ. Michael Wells - University of Alabama at BirminghamGerard J. Criner - Temple UniversityPrescott G. Woodruff - University of California, San FranciscoRussell P. Bowler - National Jewish HealthCheryl S. Pirozzi - University of UtahNadia N. Hansel - Johns Hopkins UniversityRobert A. Wise - Johns Hopkins UniversityTodd T. Brown - Johns Hopkins UniversityM. Bradley Drummond - Division of Pulmonary Diseases and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NCNeil E. AlexisWayne H. AndersonMehrdad ArjomandiIgor BarjaktarevicLori A. BatemanSurya P. BhattEugene R. BleeckerRichard C. BoucherStephanie A. ChristensonRonald G. CrystalJeffrey L. CurtisMark T. DransfieldChristine M. FreemanCraig GalbanMeiLan K. HanAnnette T. HastieYvonne HuangRobert J. KanerRichard E. KannerEric C. KleerupLisa M. LaVangeStephen C. LazarusFernando J. MartinezDeborah A. MeyersWendy C. MooreJohn D. NewellRobert PaineLaura PaulinStephen P. PetersNirupama PutchaElizabeth C. OelsnerWanda K. O’NealSanjeev RamanStephen I. RennardDonald P. TashkinLisa PostowLisa VivianoSubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS) Investigators
- Resource Type
- Journal article
- Publication Details
- Chest, Vol.157(4), pp.856-865
- DOI
- 10.1016/j.chest.2019.11.047
- PMID
- 31958447
- PMCID
- PMC7118244
- NLM abbreviation
- Chest
- ISSN
- 0012-3692
- eISSN
- 1931-3543
- Publisher
- Elsevier Inc
- Grant note
- F32HL143867-01 / National Heart, Lung, and Blood Institute (https://doi.org/10.13039/100000050) NIH (https://doi.org/10.13039/100000002) National Institutes of Health (https://doi.org/10.13039/100000002) R01HL125432-01A1 / NHLBI (https://doi.org/10.13039/100000050)
- Language
- English
- Date published
- 04/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Pulmonary, Critical Care, and Occupational Medicine; ICTS; Internal Medicine
- Record Identifier
- 9984318782702771
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