Journal article
Associations Between Cannabis Use, Polygenic Liability for Schizophrenia, and Cannabis-related Experiences in a Sample of Cannabis Users
Schizophrenia bulletin / National Institute of Mental Health, Vol.49(3), pp.778-787
05/2023
DOI: 10.1093/schbul/sbac196
PMCID: PMC10154717
PMID: 36545904
Abstract
Risk for cannabis use and schizophrenia is influenced in part by genetic factors, and there is evidence that genetic risk for schizophrenia is associated with subclinical psychotic-like experiences (PLEs). Few studies to date have examined whether genetic risk for schizophrenia is associated with cannabis-related PLEs.
We tested whether measures of cannabis involvement and polygenic risk scores (PRS) for schizophrenia were associated with self-reported cannabis-related experiences in a sample ascertained for alcohol use disorders (AUDs), the Collaborative Study on the Genetics of Alcoholism (COGA). We analyzed 4832 subjects (3128 of European ancestry and 1704 of African ancestry; 42% female; 74% meeting lifetime criteria for an AUD).
Cannabis use disorder (CUD) was prevalent in this analytic sample (70%), with 40% classified as mild, 25% as moderate, and 35% as severe. Polygenic risk for schizophrenia was positively associated with cannabis-related paranoia, feeling depressed or anhedonia, social withdrawal, and cognitive difficulties, even when controlling for duration of daily cannabis use, CUD, and age at first cannabis use. The schizophrenia PRS was most robustly associated with cannabis-related cognitive difficulties (β = 0.22, SE = 0.04, P = 5.2e-7). In an independent replication sample (N = 1446), associations between the schizophrenia PRS and cannabis-related experiences were in the expected direction and not statistically different in magnitude from those in the COGA sample.
Among individuals who regularly use cannabis, genetic liability for schizophrenia-even in those without clinical features-may increase the likelihood of reporting unusual experiences related to cannabis use.
Details
- Title: Subtitle
- Associations Between Cannabis Use, Polygenic Liability for Schizophrenia, and Cannabis-related Experiences in a Sample of Cannabis Users
- Creators
- Emma C Johnson - Washington University in St. Louis School of MedicineSarah M C Colbert - Washington University in St. Louis School of MedicinePaul W Jeffries - Washington University in St. Louis School of MedicineRebecca Tillman - Washington University in St. Louis School of MedicineTim B Bigdeli - SUNY Downstate Health Sciences UniversityNicole R Karcher - Washington University in St. Louis School of MedicineGrace Chan - University of IowaSamuel Kuperman - University of IowaJacquelyn L Meyers - SUNY Downstate Health Sciences UniversityJohn I Nurnberger - Indiana UniversityMartin H Plawecki - Indiana UniversityLouisa Degenhardt - UNSW SydneyNicholas G Martin - QIMR Berghofer Medical Research InstituteChella Kamarajan - SUNY Downstate Health Sciences UniversityMarc A Schuckit - University of California San DiegoRobin M Murray - King's College LondonDanielle M Dick - Rutgers, The State University of New JerseyHoward J Edenberg - Indiana UniversityDeepak Cyril D'Souza - VA Connecticut Healthcare SystemMarta Di Forti - South London and Maudsley NHS Foundation TrustBernice Porjesz - SUNY Downstate Health Sciences UniversityElliot C Nelson - Washington University in St. Louis School of MedicineArpana Agrawal - Washington University in St. Louis School of Medicine
- Resource Type
- Journal article
- Publication Details
- Schizophrenia bulletin / National Institute of Mental Health, Vol.49(3), pp.778-787
- DOI
- 10.1093/schbul/sbac196
- PMID
- 36545904
- PMCID
- PMC10154717
- NLM abbreviation
- Schizophr Bull
- ISSN
- 0586-7614
- eISSN
- 1745-1701
- Grant note
- R01 DA17305 / NIDA NIH HHS Comorbidity and Trauma Study (CATS) N01-HG-65403 / NIH HHS
- Language
- English
- Electronic publication date
- 12/21/2022
- Date published
- 05/2023
- Academic Unit
- Psychiatry
- Record Identifier
- 9984339405602771
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