Journal article
Associations between NIH Toolbox Emotion Battery measures and previous suicide attempt in bipolar I disorder
Journal of affective disorders, Vol.372, pp.470-480
03/01/2025
DOI: 10.1016/j.jad.2024.12.040
PMCID: PMC11902297
PMID: 39672472
Abstract
Suicide attempts are more prevalent in people with bipolar I disorder (BD-I) than in the general population. Most prior studies of suicide in BD-I have focused on separate emotion-related assays or clinician-administered scales, whereas a single, brief, and multidimensional battery of self-report measures has not yet been explored. Here, we utilized the NIH Toolbox Emotion Battery (NIHTB-EB) to assess various emotional measures, determine which were cross-sectionally associated with prior suicide attempt in BD-I, evaluate whether the NIHTB-EB could be used to identify past suicide attempt in BD-I with machine learning, and compare model performance versus using clinical mood scales. The study included 39 participants with BD-I and history of suicide attempt, 48 with BD-I without history of suicide attempt, and 58 controls. We found that 9 of the 17 measures were associated with past suicide attempt in BD-I. The initial random forest model indicated that the most important distinguishing variables were perceived stress, emotional support, anger-hostility, anger-physical aggression, perceived rejection, loneliness, and self-efficacy. Overall, the models utilizing NIHTB-EB measures performed better (69.0 % to 70.1 % accuracy) than the model containing clinical mood scale information without the NIHTB-EB measures (57.5 % accuracy). These findings suggest the NIHTB-EB could be a useful and easy-to-deploy tool in understanding the role of emotion-related measures in suicide in BD-I. Furthermore, these results highlight specific emotional subdomains that could be promising targets for longitudinal studies or interventions aimed at reducing suicide in BD-I.
Details
- Title: Subtitle
- Associations between NIH Toolbox Emotion Battery measures and previous suicide attempt in bipolar I disorder
- Creators
- Noah M GrittersGail I S HarmataDeniz BuyukgokPooya Hazegh - University of IowaKarin F HothErcole John BarsottiJess G FiedorowiczAislinn J WilliamsJenny Gringer Richards - University of IowaLeela Sathyaputri - Department of Radiology, The University of Iowa, IA, United StatesSamantha L Schmitz - University of IowaJeffrey D LongJohn A WemmieVincent A Magnotta
- Resource Type
- Journal article
- Publication Details
- Journal of affective disorders, Vol.372, pp.470-480
- DOI
- 10.1016/j.jad.2024.12.040
- PMID
- 39672472
- PMCID
- PMC11902297
- NLM abbreviation
- J Affect Disord
- ISSN
- 0165-0327
- eISSN
- 1573-2517
- Publisher
- ELSEVIER
- Grant note
- NIMH: R01MH125838, T32MH019113 Roy J. Carver Charitable Trust, NCATS: UL1TR002537 U.S. Department of Veterans AffairsLowa Neuroscience Institute Research Program of Excellence Award
This work was supported by NIMH grants R01MH111578 and R01MH125838, funding from the Roy J. Carver Charitable Trust, NCATS grant UL1TR002537, and an Iowa Neuroscience Institute Research Program of Excellence Award. J.A.W. was also supported by a Merit Award from the U.S. Department of Veterans Affairs, and G.I.S.H. was supported by NIMH grant T32MH019113. None of the funding sources influenced any aspect of study design, data collection, analysis, or writing of the manuscript.
- Language
- English
- Electronic publication date
- 12/11/2024
- Date published
- 03/01/2025
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Molecular Physiology and Biophysics; Psychiatry; Epidemiology; Iowa Neuroscience Institute; Biostatistics; Surgery; Neurosurgery
- Record Identifier
- 9984757469302771
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