Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in the Age-Related Eye Disease Study, an Ancillary Study of the Women's Health Initiative

Suzen M Moeller; Rick Voland; Lesley Tinker; Barbara A Blodi; Michael L Klein; Karen M Gehrs; Elizabeth J Johnson; D Max Snodderly; Robert B Wallace; Richard J Chappell; Niyati Parekh; Cheryl Ritenbaugh; Julie A Mares; Women's Health Initiative

doi:10.1001/archopht.126.3.354

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Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in the Age-Related Eye Disease Study, an Ancillary Study of the Women's Health Initiative

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Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in the Age-Related Eye Disease Study, an Ancillary Study of the Women's Health Initiative

Suzen M Moeller, Rick Voland, Lesley Tinker, Barbara A Blodi, Michael L Klein, Karen M Gehrs, Elizabeth J Johnson, D Max Snodderly, Robert B Wallace, Richard J Chappell, …

Archives of ophthalmology (1960), Vol.126(3), pp.354-364

03/2008

DOI: 10.1001/archopht.126.3.354

PMCID: PMC2562026

PMID: 18332316

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Abstract

To evaluate associations between nuclear cataract (determined from slitlamp photographs between May 2001 and January 2004) and lutein and zeaxanthin in the diet and serum in patients between 1994 and 1998 and macula between 2001 and 2004. A total of 1802 women aged 50 to 79 years in Iowa, Wisconsin, and Oregon with intakes of lutein and zeaxanthin above the 78th (high) and below the 28th (low) percentiles in the Women's Health Initiative Observational Study (1994-1998) were recruited 4 to 7 years later (2001-2004) into the Carotenoids in Age-Related Eye Disease Study. Women in the group with high dietary levels of lutein and zeaxanthin had a 23% lower prevalence of nuclear cataract (age-adjusted odds ratio, 0.77; 95% confidence interval, 0.62-0.96) compared with those with low levels. Multivariable adjustment slightly attenuated the association (odds ratio, 0.81; 95% confidence interval, 0.65-1.01). Women in the highest quintile category of diet or serum levels of lutein and zeaxanthin as compared with those in the lowest quintile category were 32% less likely to have nuclear cataract (multivariable-adjusted odds ratio, 0.68; 95% confidence interval, 0.48-0.97; P for trend = .04; and multivariable-adjusted odds ratio, 0.68; 95% confidence interval, 0.47-0.98; P for trend = .01, respectively). Cross-sectional associations with macular pigment density were inverse but not statistically significant. Diets rich in lutein and zeaxanthin are moderately associated with decreased prevalence of nuclear cataract in older women. However, other protective aspects of such diets may in part explain these relationships.

Aging

Cataract - blood

Retinal Pigments - metabolism

Xanthophylls - administration & dosage

Prevalence

Prospective Studies

Women's Health

Humans

Middle Aged

Risk Factors

Cataract - epidemiology

Zeaxanthins

Lens Nucleus, Crystalline - pathology

Lutein - blood

Xanthophylls - blood

Diet

Lutein - administration & dosage

Female

Aged

Details

Title: Subtitle: Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in the Age-Related Eye Disease Study, an Ancillary Study of the Women's Health Initiative
Creators: Suzen M Moeller - University of Wisconsin–Madison
Rick Voland
Lesley Tinker
Barbara A Blodi
Michael L Klein
Karen M Gehrs
Elizabeth J Johnson
D Max Snodderly
Robert B Wallace
Richard J Chappell
Niyati Parekh
Cheryl Ritenbaugh
Julie A Mares
Women's Health Initiative (Institution)
Resource Type: Journal article
Publication Details: Archives of ophthalmology (1960), Vol.126(3), pp.354-364
DOI: 10.1001/archopht.126.3.354
PMID: 18332316
PMCID: PMC2562026
NLM abbreviation: Arch Ophthalmol
ISSN: 0003-9950
eISSN: 1538-3601
Publisher: American Medical Association; United States
Grant note: DK07665 / NIDDK NIH HHS U10 EY013018 / NEI NIH HHS U10 EY013018-05 / NEI NIH HHS U10 EY013018-04 / NEI NIH HHS T32 DK007665 / NIDDK NIH HHS EY13018 / NEI NIH HHS R01 EY016886 / NEI NIH HHS U10 EY013018-03 / NEI NIH HHS U10 EY013018-02 / NEI NIH HHS U10 EY013018-01 / NEI NIH HHS
Language: English
Date published: 03/2008
Academic Unit: Epidemiology; Injury Prevention Research Center; Internal Medicine; Ophthalmology and Visual Sciences
Record Identifier: 9983980396102771

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