Journal article
Associations between alcohol use disorder polygenic score and remission in participants from high-risk families and Indiana biobank
Alcohol, clinical & experimental research, Vol.48(2), pp.283-294
02/2024
DOI: 10.1111/acer.15239
PMCID: PMC10922306
PMID: 38054532
Abstract
BACKGROUNDIn the U.S., ~50% of those who meet criteria for alcohol use disorder (AUD) during their lifetimes do not remit. We previously reported that a polygenic score for AUD (PGSAUD ) was positively associated with AUD severity as measured by DSM-5 lifetime criteria count, and AUD severity was negatively associated with remission, therefore, we hypothesized that PGSAUD would be negatively associated with remission.METHODSIndividuals of European (EA) and African ancestry (AA) from the Collaborative Study on the Genetics of Alcoholism (COGA) who met lifetime criteria for AUD, and two EA cohorts ascertained for studying liver diseases and substance use disorders, respectively, from Indiana Biobank, were included. In COGA, 12-month remission was defined as any period of ≥12 consecutive months without AUD criteria except craving and was further categorized as abstinent and non-abstinent. In Indiana Biobank, remission was defined based on ICD codes and could not be further distinguished as abstinent or non-abstinent. Sex and age were included as covariates. COGA analyses included additional adjustment for AUD severity, family history of remission, and AUD treatment history.RESULTSIn COGA EA, PGSAUD was negatively associated with 12-month and non-abstinent remission (P≤0.013, betas between -0.15 and -0.10) after adjusting for all covariates. In contrast to COGA findings, PGSAUD was positively associated with remission (P=0.004, beta=0.28) in Indiana Biobank liver diseases cohort but not in Indiana Biobank substance use disorder cohort (P=0.17, beta=0.15).CONCLUSIONSPGSAUD was negatively associated with 12-month and non-abstinent remission in COGA EA, independent of behavioral measures of AUD severity and family history of remission. The discrepant results in COGA and Indiana Biobank might reflect different ascertainment strategies: Indiana Biobank participants were older and had higher rates of liver diseases, suggesting remission due to alcohol-related health conditions that manifested in later life.
Details
- Title: Subtitle
- Associations between alcohol use disorder polygenic score and remission in participants from high-risk families and Indiana biobank
- Creators
- Dongbing Lai - Indiana University – Purdue University IndianapolisSally I-Chun Kuo - Rutgers, The State University of New JerseyLeah Wetherill - Indiana University – Purdue University IndianapolisFazil AlievMichael Zhang - Indiana University – Purdue University IndianapolisAbreu Marco - Indiana University – Purdue University IndianapolisTae-Hwi Schwantes-AnDanielle Dick - Rutgers, The State University of New JerseyMeredith W Francis - Virginia Commonwealth UniversityEmma C Johnson - Washington University in St. LouisChella Kamarajan - SUNY Downstate Health Sciences UniversitySivan Kinreich - SUNY Downstate Health Sciences UniversitySamuel Kuperman - University of IowaJacquelyn Meyers - SUNY Downstate Health Sciences UniversityJohn I Nurnberger - Indiana University – Purdue University IndianapolisYunlong Liu - Indiana University – Purdue University IndianapolisHoward J Edenberg - Indiana University – Purdue University IndianapolisBernice Porjesz - SUNY Downstate Health Sciences UniversityArpana Agrawal - Washington University in St. LouisTatiana Foroud - Indiana University – Purdue University IndianapolisMarc Schuckit - University of California San Diego Medical CenterMartin H Plawecki - Indiana University – Purdue University IndianapolisKathleen K Bucholz - Washington University in St. LouisVivia V McCutcheon - Washington University in St. Louis
- Resource Type
- Journal article
- Publication Details
- Alcohol, clinical & experimental research, Vol.48(2), pp.283-294
- DOI
- 10.1111/acer.15239
- PMID
- 38054532
- PMCID
- PMC10922306
- NLM abbreviation
- Alcohol Clin Exp Res (Hoboken)
- eISSN
- 2993-7175
- Grant note
- DOI: 10.13039/100006976, name: Lilly Endowment; DOI: 10.13039/100000027, name: National Institute on Alcohol Abuse and Alcoholism, award: U10 AA008401; DOI: 10.13039/100000002, name: National Institutes of Health, award: R01 AA030563, RR020128, UL1 TR002529
- Language
- English
- Electronic publication date
- 12/06/2023
- Date published
- 02/2024
- Academic Unit
- Psychiatry
- Record Identifier
- 9984521375602771
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