Associations between alcohol use disorder polygenic score and remission in participants from high-risk families and Indiana biobank

Dongbing Lai; Sally I-Chun Kuo; Leah Wetherill; Fazil Aliev; Michael Zhang; Abreu Marco; Tae-Hwi Schwantes-An; Danielle Dick; Meredith W Francis; Emma C Johnson; Chella Kamarajan; Sivan Kinreich; Samuel Kuperman; Jacquelyn Meyers; John I Nurnberger; Yunlong Liu; Howard J Edenberg; Bernice Porjesz; Arpana Agrawal; Tatiana Foroud; Marc Schuckit; Martin H Plawecki; Kathleen K Bucholz; Vivia V McCutcheon

doi:10.1111/acer.15239

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Associations between alcohol use disorder polygenic score and remission in participants from high-risk families and Indiana biobank

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Associations between alcohol use disorder polygenic score and remission in participants from high-risk families and Indiana biobank

Dongbing Lai, Sally I-Chun Kuo, Leah Wetherill, Fazil Aliev, Michael Zhang, Abreu Marco, Tae-Hwi Schwantes-An, Danielle Dick, Meredith W Francis, Emma C Johnson, …

Alcohol, clinical & experimental research, Vol.48(2), pp.283-294

02/2024

DOI: 10.1111/acer.15239

PMCID: PMC10922306

PMID: 38054532

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Abstract

BACKGROUNDIn the U.S., ~50% of those who meet criteria for alcohol use disorder (AUD) during their lifetimes do not remit. We previously reported that a polygenic score for AUD (PGSAUD ) was positively associated with AUD severity as measured by DSM-5 lifetime criteria count, and AUD severity was negatively associated with remission, therefore, we hypothesized that PGSAUD would be negatively associated with remission.METHODSIndividuals of European (EA) and African ancestry (AA) from the Collaborative Study on the Genetics of Alcoholism (COGA) who met lifetime criteria for AUD, and two EA cohorts ascertained for studying liver diseases and substance use disorders, respectively, from Indiana Biobank, were included. In COGA, 12-month remission was defined as any period of ≥12 consecutive months without AUD criteria except craving and was further categorized as abstinent and non-abstinent. In Indiana Biobank, remission was defined based on ICD codes and could not be further distinguished as abstinent or non-abstinent. Sex and age were included as covariates. COGA analyses included additional adjustment for AUD severity, family history of remission, and AUD treatment history.RESULTSIn COGA EA, PGSAUD was negatively associated with 12-month and non-abstinent remission (P≤0.013, betas between -0.15 and -0.10) after adjusting for all covariates. In contrast to COGA findings, PGSAUD was positively associated with remission (P=0.004, beta=0.28) in Indiana Biobank liver diseases cohort but not in Indiana Biobank substance use disorder cohort (P=0.17, beta=0.15).CONCLUSIONSPGSAUD was negatively associated with 12-month and non-abstinent remission in COGA EA, independent of behavioral measures of AUD severity and family history of remission. The discrepant results in COGA and Indiana Biobank might reflect different ascertainment strategies: Indiana Biobank participants were older and had higher rates of liver diseases, suggesting remission due to alcohol-related health conditions that manifested in later life.

Details

Title: Subtitle: Associations between alcohol use disorder polygenic score and remission in participants from high-risk families and Indiana biobank
Creators: Dongbing Lai - Indiana University – Purdue University Indianapolis
Sally I-Chun Kuo - Rutgers, The State University of New Jersey
Leah Wetherill - Indiana University – Purdue University Indianapolis
Fazil Aliev
Michael Zhang - Indiana University – Purdue University Indianapolis
Abreu Marco - Indiana University – Purdue University Indianapolis
Tae-Hwi Schwantes-An
Danielle Dick - Rutgers, The State University of New Jersey
Meredith W Francis - Virginia Commonwealth University
Emma C Johnson - Washington University in St. Louis
Chella Kamarajan - SUNY Downstate Health Sciences University
Sivan Kinreich - SUNY Downstate Health Sciences University
Samuel Kuperman - University of Iowa
Jacquelyn Meyers - SUNY Downstate Health Sciences University
John I Nurnberger - Indiana University – Purdue University Indianapolis
Yunlong Liu - Indiana University – Purdue University Indianapolis
Howard J Edenberg - Indiana University – Purdue University Indianapolis
Bernice Porjesz - SUNY Downstate Health Sciences University
Arpana Agrawal - Washington University in St. Louis
Tatiana Foroud - Indiana University – Purdue University Indianapolis
Marc Schuckit - University of California San Diego Medical Center
Martin H Plawecki - Indiana University – Purdue University Indianapolis
Kathleen K Bucholz - Washington University in St. Louis
Vivia V McCutcheon - Washington University in St. Louis
Resource Type: Journal article
Publication Details: Alcohol, clinical & experimental research, Vol.48(2), pp.283-294
DOI: 10.1111/acer.15239
PMID: 38054532
PMCID: PMC10922306
NLM abbreviation: Alcohol Clin Exp Res (Hoboken)
eISSN: 2993-7175
Grant note: DOI: 10.13039/100006976, name: Lilly Endowment; DOI: 10.13039/100000027, name: National Institute on Alcohol Abuse and Alcoholism, award: U10 AA008401; DOI: 10.13039/100000002, name: National Institutes of Health, award: R01 AA030563, RR020128, UL1 TR002529
Language: English
Electronic publication date: 12/06/2023
Date published: 02/2024
Academic Unit: Psychiatry
Record Identifier: 9984521375602771

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