Journal article
Associations between cigarette smoking, hormone therapy, and folate intake with incident colorectal cancer by TP53 protein expression level in a population-based cohort of older women
Cancer epidemiology, biomarkers & prevention, Vol.23(2), pp.350-355
02/2014
DOI: 10.1158/1055-9965.EPI-13-0780
PMCID: PMC3936962
PMID: 24343843
Abstract
Cigarette smoking (CS), hormone therapy (HT), and folate intake (FI) are each thought to influence colorectal cancer risk, but the underlying molecular mechanisms remain incompletely defined. The TP53 (p53) protein, encoded by the TP53 tumor-suppressor gene that is commonly mutated in colorectal cancer, can be readily assessed to differentiate biologically distinct colorectal cancer subtypes. In this prospective cohort study, we examined CS-, HT-, and FI-associated colorectal cancer risks by TP53 protein expression level among Iowa Women's Health Study (IWHS) participants. The IWHS recruited 41,836 randomly selected Iowa women, ages 55 to 69 years, with a valid driver's license at study entry in 1986. Self-reported exposure variables were assessed at baseline. Incident colorectal cancer cases were ascertained by annual linkage with the Iowa Cancer Registry. Archived, paraffin-embedded tissue specimens were collected and evaluated for TP53 protein expression by immunohistochemistry. Multivariate Cox regression models were fit to estimate relative risks (RR) and 95% confidence intervals (CI) for associations between CS, HT, or FI and TP53-defined colorectal cancer subtypes. Informative environmental exposure and protein expression data were available for 492 incident colorectal cancer cases: 222 (45.1%) TP53 negative, 72 (14.6%) TP53 low, and 198 (40.2%) TP53 high. Longer duration (>5 years) of HT was inversely associated with TP53 high colorectal cancers (RR, 0.50; 95% CI, 0.27-0.94). No other statistically significant associations were observed. These data support possible heterogeneous effects from HT on TP53-related pathways of colorectal carcinogenesis in older women.
Details
- Title: Subtitle
- Associations between cigarette smoking, hormone therapy, and folate intake with incident colorectal cancer by TP53 protein expression level in a population-based cohort of older women
- Creators
- Lori S Tillmans - Mayo ClinicRobert A VierkantAlice H Wang - Mayo ClinicN Jewel SamadderCharles F LynchKristin E AndersonAmy J FrenchRobert W HaileLisa J HarnackJohn D PotterSusan L SlagerThomas C SmyrkStephen N ThibodeauJames R CerhanPaul J Limburg
- Resource Type
- Journal article
- Publication Details
- Cancer epidemiology, biomarkers & prevention, Vol.23(2), pp.350-355
- Publisher
- United States
- DOI
- 10.1158/1055-9965.EPI-13-0780
- PMID
- 24343843
- PMCID
- PMC3936962
- ISSN
- 1055-9965
- eISSN
- 1538-7755
- Grant note
- P30 ES005605 / NIEHS NIH HHS CA107333 / NCI NIH HHS R01 CA107333 / NCI NIH HHS HHSN261201000032C / NCI NIH HHS P30 CA086862 / NCI NIH HHS P30 CA015083 / NCI NIH HHS
- Language
- English
- Date published
- 02/2014
- Academic Unit
- Epidemiology
- Record Identifier
- 9983995037002771
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