Journal article
Associations between emphysema-like lung on CT and incident airflow limitation: a general population-based cohort study
Thorax, Vol.73(5), pp.486-488
05/2018
DOI: 10.1136/thoraxjnl-2017-210842
PMID: 29074811
Abstract
Emphysema on CT is associated with accelerated lung function decline in heavy smokers and patients with COPD; however, in the general population, it is not known whether greater emphysema-like lung on CT is associated with incident COPD. We used data from 2045 adult participants without initial prebronchodilator airflow limitation, classified by FEV1/FVC<0.70, in the Multi-Ethnic Study of Atherosclerosis. Emphysema-like lung on baseline cardiac CT, defined as per cent low attenuation areas<—950HU>upper limit of normal, was associated with increased odds of incident airflow limitation at 5-year follow-up on both prebronchodilator (adjusted OR 2.62, 95% CI 1.47 to 4.67) and postbronchodilator (adjusted OR 4.38, 95% CI 1.63 to 11.74) spirometry, independent of smoking history. These results support investigation into whether emphysema-like lung could be informative for COPD risk stratification.
Details
- Title: Subtitle
- Associations between emphysema-like lung on CT and incident airflow limitation: a general population-based cohort study
- Creators
- Elizabeth C Oelsner - Department of Epidemiology, Columbia University Mailman School of Public Health, New York City, New York, USABenjamin M Smith - Respiratory Division, McGill University, Montreal, Quebec, CanadaEric A Hoffman - Department of Radiology, University of Iowa, Iowa City, Iowa, USAAaron R Folsom - Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USASteven M Kawut - School of Medicine, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Philadelphia, Pennsylvania, USAJoel D Kaufman - Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USAAni Manichaikul - Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, Virginia, USADavid J Lederer - Department of Medicine, Columbia University College of Physicians and Surgeons, New York City, New York, USAJoseph E Schwartz - Department of Medicine, Columbia University College of Physicians and Surgeons, New York City, New York, USAKarol E Watson - Division of Cardiology, UCLA School of Medicine, Los Angeles, California, USAPaul L Enright - Department of Medicine, University of Arizona, Tucson, Arizona, USAJohn H M Austin - Department of Medicine, Columbia University College of Physicians and Surgeons, New York City, New York, USAJoao A C Lima - Department of Cardiology, Johns Hopkins University, Baltimore, Maryland, USASteven J Shea - Department of Epidemiology, Columbia University Mailman School of Public Health, New York City, New York, USARobert G Barr - Department of Epidemiology, Columbia University Mailman School of Public Health, New York City, New York, USA
- Resource Type
- Journal article
- Publication Details
- Thorax, Vol.73(5), pp.486-488
- DOI
- 10.1136/thoraxjnl-2017-210842
- PMID
- 29074811
- ISSN
- 0040-6376
- eISSN
- 1468-3296
- Grant note
- DOI: 10.13039/100000139, name: U.S. Environmental Protection Agency; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute; DOI: 10.13039/100000097, name: National Center for Research Resources
- Language
- English
- Date published
- 05/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984051597702771
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