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Associations between intake of folate and related micronutrients with molecularly defined colorectal cancer risks in the Iowa Women's Health Study
Journal article   Peer reviewed

Associations between intake of folate and related micronutrients with molecularly defined colorectal cancer risks in the Iowa Women's Health Study

Anthony A Razzak, Amy S Oxentenko, Robert A Vierkant, Lori S Tillmans, Alice H Wang, Daniel J Weisenberger, Peter W Laird, Charles F Lynch, Kristin E Anderson, Amy J French, …
Nutrition and cancer, Vol.64(7), pp.899-910
2012
DOI: 10.1080/01635581.2012.714833
PMCID: PMC3584680
PMID: 23061900
url
https://www.ncbi.nlm.nih.gov/pmc/articles/3584680View
Open Access

Abstract

Folate and related micronturients may affect colorectal cancer (CRC) risk, but the molecular mechanism(s) remain incompletely defined. We analyzed associations between dietary folate, vitamin B6, vitamin B12, and methionine with incident CRC, overall and by microsatellite instability (MSS/MSI-L or MSI-H), CpG island methylator phenotype (CIMP-negative or CIMP-positive), BRAF mutation (negative or positive), and KRAS mutation (negative or positive) status in the prospective, population-based Iowa Women's Health Study (IWHS; 55-69 years at baseline; n = 41,836). Intake estimates were obtained from baseline, self-reported food frequency questionnaires. Molecular marker data were obtained for 514 incident CRC cases. Folate intake was inversely associated with overall CRC risk in age-adjusted Cox regression models, whereas methionine intake was inversely associated with overall CRC risk in multivariable-adjusted models [relative risk (RR) = 0.81; 95% CI = 0.69-0.95; P trend = 0.001 and RR = 0.72; 95% CI = 0.54-0.96; P trend = 0.03 for highest vs. lowest quartiles, respectively]. None of the dietary exposures were associated with MSI, CIMP, BRAF, or KRAS defined CRC subtypes. These data provide minimal support for major effects from the examined micronutrients on overall or molecularly defined CRC risks in the IWHS cohort.
 Genetic Markers Phenotype Mutation Multivariate Analysis ras Proteins - genetics Life Style Microsatellite Instability Proto-Oncogene Proteins p21(ras) Prospective Studies Women's Health Follow-Up Studies Nutrition Surveys Colorectal Neoplasms - genetics Humans Middle Aged ras Proteins - metabolism Folic Acid - administration & dosage Vitamin B 6 - administration & dosage Incidence DNA Methylation Female Iowa - epidemiology Surveys and Questionnaires Micronutrients - administration & dosage Proto-Oncogene Proteins B-raf - metabolism Colorectal Neoplasms - epidemiology Proto-Oncogene Proteins - metabolism Vitamin B 12 - administration & dosage Risk Factors Proportional Hazards Models Feeding Behavior Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins B-raf - genetics CpG Islands Aged

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