Associations between longitudinal fluoride intakes from birth to age 23 and multi-row detector computed tomography bone densitometry outcomes at age 23

Gurjot Kaur Bhatia; Steven M Levy; John J Warren; Oscar A Rysavy; Punam K Saha; Xiaoliu Zhang; Erliang Zeng

doi:10.1111/jphd.12643

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Associations between longitudinal fluoride intakes from birth to age 23 and multi-row detector computed tomography bone densitometry outcomes at age 23

Journal article

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Associations between longitudinal fluoride intakes from birth to age 23 and multi-row detector computed tomography bone densitometry outcomes at age 23

Gurjot Kaur Bhatia, Steven M Levy, John J Warren, Oscar A Rysavy, Punam K Saha, Xiaoliu Zhang and Erliang Zeng

Journal of public health dentistry, Vol.84(4), pp.428-438

Autumn 2024

DOI: 10.1111/jphd.12643

PMCID: PMC11619560

PMID: 39243208

Appears in UI Libraries Support Open Access

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Abstract

To assess the relationships between longitudinal fluoride intakes and bone densitometry outcomes in young adults.OBJECTIVESTo assess the relationships between longitudinal fluoride intakes and bone densitometry outcomes in young adults.Data were analyzed from the Iowa Fluoride Study and Iowa Bone Development Study, which followed 1,882 infants from birth in 1992. Daily fluoride intakes were assessed using detailed questionnaires sent every 1.5-6 months, and multi-row detector computed tomography (MDCT) scans of distal tibia were obtained from 330 participants aged 23 years. Sex-specific bivariate and multivariable associations with MDCT outcomes were examined using linear regression. Because of the multiple statistical analyses being conducted, p-values < 0.01 were considered statistically significant.METHODSData were analyzed from the Iowa Fluoride Study and Iowa Bone Development Study, which followed 1,882 infants from birth in 1992. Daily fluoride intakes were assessed using detailed questionnaires sent every 1.5-6 months, and multi-row detector computed tomography (MDCT) scans of distal tibia were obtained from 330 participants aged 23 years. Sex-specific bivariate and multivariable associations with MDCT outcomes were examined using linear regression. Because of the multiple statistical analyses being conducted, p-values < 0.01 were considered statistically significant.In fully adjusted analyses, no statistically significant (p < 0.01) or suggestive (0.01 < p < 0.05) associations were found between period-specific or cumulative fluoride intake and bone measures for either sex, although there were suggestive positive relationships in unadjusted analyses.RESULTSIn fully adjusted analyses, no statistically significant (p < 0.01) or suggestive (0.01 < p < 0.05) associations were found between period-specific or cumulative fluoride intake and bone measures for either sex, although there were suggestive positive relationships in unadjusted analyses.Longitudinal fluoride intakes had little association with bone measures at age 23. As there were no adverse effects from fluoride intake on bone health in young adults, results support the continued use of fluorides, particularly community water fluoridation is the most cost-effective method of dental caries prevention.CONCLUSIONSLongitudinal fluoride intakes had little association with bone measures at age 23. As there were no adverse effects from fluoride intake on bone health in young adults, results support the continued use of fluorides, particularly community water fluoridation is the most cost-effective method of dental caries prevention.

UIOWA OA Agreement

bone densitometry

distal tibia

fluoride intake

multi-detector computed tomography (MDCT)

young adults

Details

Title: Subtitle: Associations between longitudinal fluoride intakes from birth to age 23 and multi-row detector computed tomography bone densitometry outcomes at age 23
Creators: Gurjot Kaur Bhatia - University of Iowa
Steven M Levy - University of Iowa
John J Warren - University of Iowa
Oscar A Rysavy - University of Iowa
Punam K Saha - University of Iowa
Xiaoliu Zhang - University of Iowa
Erliang Zeng - University of Iowa
Resource Type: Journal article
Publication Details: Journal of public health dentistry, Vol.84(4), pp.428-438
DOI: 10.1111/jphd.12643
PMID: 39243208
PMCID: PMC11619560
NLM abbreviation: J Public Health Dent
ISSN: 1752-7325
eISSN: 1752-7325
Publisher: Wiley; HOBOKEN
Grant note: U.S. National Institutes of Health: M01-RR00059, R01-DE09551, R01-DE12101, R03-DE023784, R56-DE012101, UL1-RR024979, UL1-TR000442, UL1-TR001013
U.S. National Institutes of Health,Grant/Award Numbers: M01-RR00059,R01-DE09551, R01-DE12101, R03-DE023784,R56-DE012101, UL1-RR024979,UL1-TR000442, UL1-TR001013; Delta Dentalof Iowa Foundation; Roy J. Carver Charitable Trust; Dr. Levy's Wright-Bush-Shreves Endowed Professor Fund at the University of Iowa.
Language: English
Electronic publication date: 09/07/2024
Date published season: Autumn 2024
Date published: 2024
Academic Unit: Preventive and Community Dentistry; Radiology; Electrical and Computer Engineering; Epidemiology; Iowa Neuroscience Institute; Biostatistics; Dental Research
Record Identifier: 9984701559002771

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