Journal article
Associations between neuropsychiatric symptoms of affective and vegetative domains and brain morphology in aging people with mild cognitive impairment and Alzheimer's disease
International journal of geriatric psychiatry, Vol.38(6), e5952
06/23/2023
DOI: 10.1002/gps.5952
Abstract
Objective
Neuropsychiatric symptoms (NPS) are common in mild cognitive impairment (MCI) and even more in Alzheimer's disease (AD). The symptom-based cluster including nighttime disturbances, depression, appetite changes, anxiety, and apathy (affective and vegetative symptoms) was associated with an increased risk of dementia in MCI and has common neuroanatomical associations. Our objective was to investigate the differences in brain morphology associations with affective and vegetative symptoms between three groups: cognitively normal older adults (CN), MCI and AD.
Material and Methods
Alzheimer's Disease Neuroimaging Initiative data of 223 CN, 367 MCI and 175 AD, including cortical volumes, surface areas and thicknesses and severity scores of the five NPS were analyzed. A whole-brain vertex-wise general linear model was performed to test for intergroup differences (CN-MCI, CN-AD, AD-MCI) in brain morphology associations with five NPS. Multiple regressions were conducted to investigate cortical change as a function of NPS severity in the AD-MCI contrast.
Results
We found (1) signature differences in nighttime disturbances associations with prefrontal regions in AD-MCI, (2) signature differences in NPS associations with temporal regions in AD-MCI for depression and in CN-AD for anxiety, (3) decreased temporal metrics in MCI as nighttime disturbances and depression severity increased, (4) decreased pars triangularis metrics in AD as nighttime disturbances and apathy severity increased.
Conclusion
Each NPS seems to have a signature on brain morphology. Affective and vegetative NPS were primarily associated with prefrontal and temporal regions. These signatures open the possibility of potential future assessments of links between brain morphology and NPS on an individual level.
Details
- Title: Subtitle
- Associations between neuropsychiatric symptoms of affective and vegetative domains and brain morphology in aging people with mild cognitive impairment and Alzheimer's disease
- Creators
- Adriana Cannizzaro - Institut Universitaire de Gériatrie de MontréalLucas Ronat - Institut Universitaire de Gériatrie de MontréalLyna Mariam El Haffaf - Institut Universitaire de Gériatrie de MontréalAlexandru Hanganu - Institut Universitaire de Gériatrie de MontréalAlzheimer's Disease Neuroimaging Initiative (ADNI)
- Contributors
- Delwyn D Miller (Contributor) - University of Iowa, PsychiatryLaura L Boles Ponto (Contributor) - University of Iowa, RadiologyKaren Ekstam Smith (Contributor)Hristina K Koleva (Contributor) - University of Iowa, PsychiatryHyungSub Shim (Contributor) - University of Iowa, NeurologyKi Won Nam (Contributor)Susan K Schultz (Contributor) - University of Iowa, Psychiatry
- Resource Type
- Journal article
- Publication Details
- International journal of geriatric psychiatry, Vol.38(6), e5952
- DOI
- 10.1002/gps.5952
- ISSN
- 0885-6230
- eISSN
- 1099-1166
- Grant note
- DOI: 10.13039/501100000156, name: Fonds de Recherche du Québec - Santé; DOI: 10.13039/501100009307, name: Parkinson Canada, award: 2018‐00355
- Language
- English
- Date published
- 06/23/2023
- Academic Unit
- Radiology; Neurology; Psychiatry
- Record Identifier
- 9984443233902771
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