Associations between periconceptional alcohol consumption and craniosynostosis, omphalocele, and gastroschisis

Sandra Richardson; Marilyn L Browne; Sonja A Rasmussen; Charlotte M Druschel; Lixian Sun; Ethylin Wang Jabs; Paul A Romitti; National Birth Defects Prevention Study

doi:10.1002/bdra.20823

Back

Associations between periconceptional alcohol consumption and craniosynostosis, omphalocele, and gastroschisis

Journal article

Open access

Peer reviewed

Associations between periconceptional alcohol consumption and craniosynostosis, omphalocele, and gastroschisis

Sandra Richardson, Marilyn L Browne, Sonja A Rasmussen, Charlotte M Druschel, Lixian Sun, Ethylin Wang Jabs, Paul A Romitti and National Birth Defects Prevention Study

Birth defects research. A Clinical and molecular teratology, Vol.91(7), pp.623-630

07/2011

DOI: 10.1002/bdra.20823

PMCID: PMC6042859

PMID: 21630421

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/6042859View

Open Access

Abstract

Alcohol consumption during pregnancy is known to be associated with certain birth defects, but the risk of other birth defects is less certain. The authors examined associations between maternal alcohol consumption during pregnancy and craniosynostosis, omphalocele, and gastroschisis among participants in the National Birth Defects Prevention Study, a large, multicenter case-control study. A total of 6622 control infants and 1768 infants with birth defects delivered from 1997-2005 were included in the present analysis. Maternal alcohol consumption was assessed as any periconceptional consumption (1 month prepregnancy through the third pregnancy month), and by quantity-frequency, duration, and beverage type. Alcohol consumption throughout pregnancy was explored for craniosynostosis since the period of development may extend beyond the first trimester. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression analysis. OR were adjusted for age, race/ethnicity, and state of residence at time of infant's birth. Gastroschisis OR were also adjusted for periconceptional smoking. Periconceptional alcohol consumption and craniosynostosis showed little evidence of an association (OR = 0.92; CI: 0.78-1.08), but alcohol consumption in the second (OR = 0.65; CI: 0.47-0.92) and third trimesters (OR = 0.68; CI: 0.49-0.95) was inversely associated with craniosynostosis. Periconceptional alcohol consumption was associated with omphalocele (OR = 1.50; CI: 1.15-1.96) and gastroschisis (OR = 1.40; CI: 1.17-1.67). Results suggest that maternal periconceptional alcohol consumption is associated with omphalocele and gastroschisis, and second and third trimester alcohol consumption are inversely associated with craniosynostosis.

Pregnancy

Craniosynostoses - epidemiology

Humans

Risk Factors

Gastroschisis - epidemiology

Hernia, Umbilical - epidemiology

Infant

Male

Alcohol Drinking - adverse effects

Maternal Exposure

Young Adult

Adolescent

Adult

Female

Odds Ratio

Child

Pregnancy Trimesters

Details

Title: Subtitle: Associations between periconceptional alcohol consumption and craniosynostosis, omphalocele, and gastroschisis
Creators: Sandra Richardson - Congenital Malformations Registry, Bureau of Environmental and Occupational Epidemiology, New York State Department of Health, Troy, USA. sdr06@health.state.ny.us
Marilyn L Browne
Sonja A Rasmussen
Charlotte M Druschel
Lixian Sun
Ethylin Wang Jabs
Paul A Romitti
National Birth Defects Prevention Study
Resource Type: Journal article
Publication Details: Birth defects research. A Clinical and molecular teratology, Vol.91(7), pp.623-630
DOI: 10.1002/bdra.20823
PMID: 21630421
PMCID: PMC6042859
NLM abbreviation: Birth Defects Res A Clin Mol Teratol
ISSN: 1542-0752
eISSN: 1542-0760
Publisher: Wiley; United States
Grant note: U01 DD000492 / NCBDD CDC HHS U01 DD000487 / NCBDD CDC HHS
Language: English
Date published: 07/2011
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9983995052602771

Metrics

28 Record Views

42 Times Cited - Web of Science