Journal article
Associations between tissue-based CD3+ T-lymphocyte count and colorectal cancer survival in a prospective cohort of older women
Molecular carcinogenesis, Vol.60(1), pp.15-24
01/2021
DOI: 10.1002/mc.23267
PMCID: PMC7745624
PMID: 33200476
Abstract
Tumor-infiltrating lymphocytes in colorectal cancer (CRC) predict better survival. However, associations between T-lymphocyte count in histologically normal tissues from patients with CRC and survival remain uncertain. We examined associations of CD3+ T-cells in colorectal tumor and histologically normal tissues with CRC-specific and all-cause mortality in the prospective Iowa Women's Health Study. Tissue microarrays were constructed using paraffin-embedded colorectal tissue samples from 464 women with tumor tissues and 314 women with histologically normal tissues (55-69 years at baseline) diagnosed with incident CRC from 1986 to 2002 and followed through 2014 (median follow-up 20.5 years). Three tumor and two histologically normal tissue cores for each patient were immunostained using CD3+ antibody and quantified, and the counts were averaged across the cores in each tissue. Cox proportional hazards regression estimated hazard ratios (HR) and 95% confidence interval (CI) for CRC-specific and all-cause mortality. After adjustment for age at diagnosis, body mass index, smoking status, tumor grade, and stage, HRs (95% CI) for the highest versus lowest tertile of tumor CD3+ score were 0.59 (0.38-0.89) for CRC-specific mortality and 0.82 (0.63-1.05) for all-cause mortality; for histologically normal CD3+ score, the corresponding HRs (95% CI) were 0.47 (0.19-1.17) and 0.50 (0.27-0.90), respectively. The CD3+ score combining the tumor and histologically normal scores was inversely associated with CRC-specific and all-cause mortality. Although the association between tumor CD3+ score and all-cause mortality was not significant, both higher CD3+ T-lymphocyte counts in tumor and histologically normal scores tended to be associated with lower CRC-specific and all-cause mortality.
Details
- Title: Subtitle
- Associations between tissue-based CD3+ T-lymphocyte count and colorectal cancer survival in a prospective cohort of older women
- Creators
- Mosunmoluwa Oyenuga - Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USARobert A Vierkant - Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USACharles F Lynch - Department of Epidemiology, University of Iowa, Iowa City, Iowa, USAThomas Pengo - University of Minnesota Informatics Institute, University of Minnesota, Minneapolis, Minnesota, USALori S Tillmans - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USAJames R Cerhan - Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USATimothy R Church - Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USADeAnn Lazovich - Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USAKristin E Anderson - Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USAPaul J Limburg - Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USAAnna E Prizment - Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
- Resource Type
- Journal article
- Publication Details
- Molecular carcinogenesis, Vol.60(1), pp.15-24
- DOI
- 10.1002/mc.23267
- PMID
- 33200476
- PMCID
- PMC7745624
- NLM abbreviation
- Mol Carcinog
- ISSN
- 0899-1987
- eISSN
- 1098-2744
- Grant note
- R01 CA107333 / NCI NIH HHS HHSN261201000032C / NCI NIH HHS UL1 TR000114 / NCATS NIH HHS UL1 TR002494 / NCATS NIH HHS P30 CA086862 / NCI NIH HHS R01 CA039742 / NCI NIH HHS
- Language
- English
- Date published
- 01/2021
- Academic Unit
- Epidemiology
- Record Identifier
- 9984214666802771
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