Associations between urinary metabolites of di(2-ethylhexyl) phthalate and reproductive hormones in fertile men

J. Mendiola; N. Jørgensen; A.-M. Andersson; A. M. Calafat; M.J. Silva; J.B. Redmon; A. Sparks; E.Z. Drobnis; C. Wang; F. Liu; S.H. Swan

doi:10.1111/j.1365-2605.2010.01095.x

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Associations between urinary metabolites of di(2-ethylhexyl) phthalate and reproductive hormones in fertile men

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Associations between urinary metabolites of di(2-ethylhexyl) phthalate and reproductive hormones in fertile men

J. Mendiola, N. Jørgensen, A.-M. Andersson, A. M. Calafat, M.J. Silva, J.B. Redmon, A. Sparks, E.Z. Drobnis, C. Wang, F. Liu, …

International journal of andrology, Vol.34(4), pp.369-378

07/14/2010

DOI: 10.1111/j.1365-2605.2010.01095.x

PMCID: PMC3529299

PMID: 20633195

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Abstract

Widely used man-made chemicals, including phthalates, can induce hormonal alterations through a variety of cellular and molecular mechanisms. A number of rodent and observational studies have consistently demonstrated the anti-androgenic effect of several phthalates. However, there are only limited data on the relationship between exposure to these chemicals and reproductive hormone levels in men. All men ( n = 425) were partners of pregnant women who participated in the Study for Future Families in five US cities and provided urine and serum samples on the same day. Eleven phthalate metabolites were measured in urine and serum samples were analysed for reproductive hormones, including follicle-stimulating hormone, luteinizing hormone, testosterone, inhibin B and oestradiol and sex hormone-binding globulin (SHBG). Pearson correlations and parametric tests were used for unadjusted analyses, and multiple linear regression analysis was performed controlling for appropriate covariates. We observed weak or no associations with urinary phthalates other than di(2-ethylhexyl) phthalate (DEHP). All measures of testosterone [total, calculated free testosterone and the free androgen index (FAI)] were inversely correlated with the urinary concentrations of four DEHP metabolites. After adjustment by appropriate covariates, there was no longer an association between urinary DEHP metabolite concentrations and total testosterone levels; however, FAI was significantly associated with the urinary concentrations of several DEHP metabolites. SHBG was positively related to the urinary concentrations of mono(2-ethylhexyl) phthalate, but not with other DEHP metabolites, an association that was attenuated after adjustment. Our results suggest that DEHP exposure of fertile men is associated with minor alterations of markers of free testosterone.

anti-androgens

di(2-ethylhexyl) phthalate metabolites

endocrine disruptors

male hormones

phthalates

Details

Title: Subtitle: Associations between urinary metabolites of di(2-ethylhexyl) phthalate and reproductive hormones in fertile men
Creators: J. Mendiola - University of Rochester
N. Jørgensen - University of Copenhagen
A.-M. Andersson - University of Copenhagen
A. M. Calafat - Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA.
M.J. Silva - Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA.
J.B. Redmon - University of Minnesota
A. Sparks - Department of Obstetrics and Gynecology, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA University Department of Growth and Reproduction, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA Departments of Medicine and Urologic Surgery, University of Minnesota Medical School, Minneapolis, MN Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IO Department of Obstetrics, Gynecology and Women’s Health, School of Medicine, University of Missouri, Columbia, MO Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA, USA
E.Z. Drobnis - University of Missouri
C. Wang - The Lundquist Institute
F. Liu - University of Rochester
S.H. Swan - University of Rochester
Resource Type: Journal article
Publication Details: International journal of andrology, Vol.34(4), pp.369-378
DOI: 10.1111/j.1365-2605.2010.01095.x
PMID: 20633195
PMCID: PMC3529299
NLM abbreviation: Int J Androl
ISSN: 0105-6263
eISSN: 1365-2605
Grant note: R01 ES009916 || ES / National Institute of Environmental Health Sciences : NIEHS
Language: English
Date published: 07/14/2010
Academic Unit: Obstetrics and Gynecology
Record Identifier: 9984318221402771

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