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Associations of Accelerometer-Determined Sedentary and Physical Activity Behaviors with Heart Failure Biomarkers During Midlife: CARDIA Study
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Associations of Accelerometer-Determined Sedentary and Physical Activity Behaviors with Heart Failure Biomarkers During Midlife: CARDIA Study

Kelley Pettee Gabriel, Bjoern Hornikel, Erin E Dooley, Baojiang Chen, Sylvia E Badon, Ankeet S Bhatt, Mercedes R Carnethon, David R Jacobs Jr, Sadiya S Khan, Joao A C Lima, …
Medicine and science in sports and exercise, Vol.58(4), pp.776-785
04/2026
DOI: 10.1249/MSS.0000000000003895
PMCID: PMC12629602
PMID: 41250299

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Abstract

Few studies have examined the longitudinal associations of accelerometer-based measures of sedentary and physical activity behaviors with subclinical heart failure (HF) in midlife. This is a key gap given an improved understanding of modifiable factors associated with HF risk may better inform prevention strategies. We hypothesize that more time in light intensity physical activity (LIPA) and/or moderate or vigorous intensity physical activity (MVPA) and less sedentary time will be related to lower levels of HF biomarkers [N-terminal pro B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hscTnT)] across midlife. Data are from 2,494 Coronary Artery Risk Development in Young Adults (CARDIA) participants without clinical HF [58.9% women, 45.7% Black persons, mean (± SD) aged 51.1 ± 7.2 years at the baseline contributing exam] with at least one occurrence of concurrent valid accelerometer (ActiGraph 7164/GT3X; Ametris; Pensacola, FL) wear and HF biomarkers at the CARDIA Year 20, 30 and/or Year 35 follow-up examinations. Adjusted linear mixed effects models were used to estimate the associations. Heterogeneity in the associations by the four race-sex groups represented in CARDIA was also examined. In the fully adjusted models, every 5-minute higher MVPA was associated with -0.05 (95% CI: -0.09 to -0.01, p = 0.022) lower hscTnT. The associations of sedentary and LIPA with hscTnT and associations of any accelerometer estimate with NT-proBNP were not statistically supported (all p>0.05). Findings were similar when clinically relevant categories of HF biomarker outcomes were used in the analysis. Findings address research gaps in the literature and demonstrate the importance of MVPA during the midlife transition for HF prevention before the onset of overt signs or symptoms.
 ACCELEROMETER COHORT STUDY SEDENTARY BEHAVIOR HEART FAILURE RISK PHYSICAL ACTIVITY

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